The netrin‐1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson’s disease

Mechanisms that determine the survival of midbrain dopaminergic (mDA) neurons in the adult central nervous system (CNS) are not fully understood. Netrins are a family of secreted proteins that are essential for normal neural development. In the mature CNS, mDA neurons express particularly high level...

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Bibliographic Details
Published in:Journal of neurochemistry 2022-05, Vol.161 (3), p.254-265
Main Authors: Lo, Pik‐Shan, Rymar, Vladimir V., Kennedy, Timothy E., Sadikot, Abbas F.
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animal models
Animals
Apoptosis
calbindin D‐28k
Cell death
Central nervous system
Colorectal cancer
Colorectal carcinoma
DCC protein
DCC Receptor - metabolism
Degeneration
Deletion
dopamine
Dopamine receptors
Dopaminergic Neurons - metabolism
Gene dosage
Heterozygotes
Lethality
LoxP gene
Mesencephalon
Mesencephalon - metabolism
Mice
Movement disorders
Netrin Receptors - metabolism
Netrin-1 - metabolism
netrin‐1
Neurodegenerative diseases
Neurons
Original
ORIGINAL ARTICLES
Parkinson Disease - genetics
Parkinson Disease - metabolism
Parkinson's disease
Receptors
Subpopulations
Substantia nigra
Survival
unbiased stereology
ventral tegmental area
Ventral tegmentum
Young adults
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