Self‐reported flares among people living with inflammatory bowel disease are associated with stress and worry but not associated with recent diet changes: The Manitoba Living with IBD Study

• Published in: JPEN. Journal of parenteral and enteral nutrition 2022-09, Vol.46 (7), p.1686-1698
• Main Authors: Vagianos, Kathy, Shafer, Leigh Anne, Witges, Kelcie, Graff, Lesley A., Targownik, Laura E., Bernstein, Charles N.
• Format: Article
• Language: English
• Subjects: diet; disease flare; inflammatory bowel disease; stress
• ISSN: 0148-6071; 1941-2444
• DOI: 10.1002/jpen.2349

Background In this matched case‐control longitudinal study among people living with inflammatory bowel disease (IBD), we investigated beliefs about what triggers a flare. Methods Adults with confirmed IBD and active disease within 2 years were enrolled in the Manitoba Living with IBD Study and followed biweekly with online surveys for 1 year. The 7‐point IBD Symptom Change Indicator was used for participant identification of a flare. Flare cases were matched to non‐flare controls by sex and disease type. Members of each matched pair completed supplementary information on diet changes and psychological functioning in the previous 2 weeks and provided stool samples to assess fecal calprotectin (FCAL). Results Of 128 enrolled participants, 95 matched flare/non‐flare pairs were created. Those reporting a flare were more likely to have elevated FCAL (51% vs 34% among non‐flares, P = 0.043). Although 61% of study participants believed at baseline that a food may trigger flares, and 25% of those in a flare believed that a food may have triggered their current flare, there was no difference in consumption of assessed foods between flares and non‐flares in the previous 2 weeks. Patients with flares were more likely to be having difficulties in emotional state than controls (40% vs 18%, P = 0.001) and more likely to be stressed or worried (64% vs 33%, P = 0.001). Conclusion Although a majority of individuals with IBD believe that specific foods trigger their disease flares, this was not supported by the current findings. Recent psychological functioning was associated with self‐reported IBD flare.