Atroposelective Synthesis of 1,1′‐Bipyrroles Bearing a Chiral N−N Axis: Chiral Phosphoric Acid Catalysis with Lewis Acid Induced Enantiodivergence

We present herein a highly efficient atroposelective synthesis of axially chiral 1,1′‐bipyrroles bearing an N−N linkage from simple hydrazine and 1,4‐diones. Further product derivatizations led to axially chiral bifunctional compounds with high potential in asymmetric catalysis. For this chrial phos...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-04, Vol.61 (16), p.e202200371-n/a
Main Authors: Gao, Yaru, Wang, Luo‐Yu, Zhang, Tao, Yang, Bin‐Miao, Zhao, Yu
Format: Article
Language:English
Subjects:
Atroposelectivity
Catalysis
Chiral N−N Axis
Diketones
Enantiodivergence
Heterocycle
Hydrazine
Hydrazines
Lewis acid
Lewis Acids
Organocatalysis
Phosphoric acid
Phosphoric Acids
Stereoisomerism
Synthesis
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