Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis

• Published in: Current medical science 2022-06, Vol.42 (3), p.483-490
• Main Authors: Huang, Mei, Li, Zi-xi, Chen, Juan, Chen, Ling, Li, Yuan-yuan
• Format: Article
• Language: English
• Subjects: Medicine; Medicine & Public Health
• ISSN: 2096-5230; 2523-899X
• DOI: 10.1007/s11596-022-2525-4

Objective Cerebral ischemia/reperfusion (I/R) is a potential factor for lethal injury, and currently lacks effective remedies. Bauhinia championii extracts (BCEs) have been reported to exhibit anti-oxidative and anti-hypoxia properties. The current work aimed to study whether BCE could alleviate neuronal injury caused by I/R. Methods To investigate the protective effects of BCE, oxygen-glucose deprivation/reperfusion (OGD/R) was applied to the HT22 cell line in vitro and to a cerebral I/R mouse model in vivo . Results Under OGD/R, the survival of HT22 cells was significantly prolonged after treatment with BCE. In vivo , BCE significantly reduced the infarct area and decreased neuronal apoptosis caused by I/R. It was further found that OGD/R could trigger endoplasmic reticulum (ER) stress and induce ER stress-mediated neuronal apoptosis in vivo and in vitro , while BCE could effectively alleviate ER stress and neuronal apoptosis. Conclusion These results suggested that BCE exhibits neuroprotective effects by reducing ER stress-mediated apoptosis after cerebral I/R injury. BCE may therefore be an effective therapeutic regimen against cerebral I/R damage.