Risk of treatment discontinuation and psychiatric hospitalization associated with early dose reduction of antipsychotic treatment in first‐episode schizophrenia: A nationwide, health insurance data–based study

Aim We investigated the impact of early dose reduction of antipsychotic treatment on the risk of treatment discontinuation and psychiatric hospitalization in patients with first‐episode schizophrenia (FES). Methods The Health Insurance Review Agency database in South Korea was used to include 16 153...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry and clinical neurosciences 2022-05, Vol.76 (5), p.195-200
Main Authors: Joo, Sung Woo, Kim, Harin, Jo, Young Tak, Ahn, Soojin, Choi, Young Jae, Choi, Woohyeok, Park, Soyeon, Lee, Jungsun
Format: Article
Language:English
Subjects:
antipsychotic
Antipsychotics
dose reduction
Drug dosages
first‐episode schizophrenia
Health insurance
Hospitalization
Mental disorders
Olanzapine
Patients
Psychotropic drugs
Schizophrenia
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim We investigated the impact of early dose reduction of antipsychotic treatment on the risk of treatment discontinuation and psychiatric hospitalization in patients with first‐episode schizophrenia (FES). Methods The Health Insurance Review Agency database in South Korea was used to include 16 153 patients with FES. At 6 months from their diagnosis, the patients were categorized by the magnitude of dose reduction (no reduction, 0%–50%, and >50%). With a reference of no reduction, the risk of treatment discontinuation and psychiatric hospitalization associated with dose reduction in the 1‐year follow‐up period after the first 6 months was examined with a Cox proportional hazard ratio model stratified by the mean daily olanzapine‐equivalent dose in the first 3 months (20 mg/day). Results A >50% dose reduction was associated with an increased risk of treatment discontinuation in all subgroups (
ISSN:1323-1316
1440-1819
DOI:10.1111/pcn.13341