Real-world outcomes of systemic therapy in locally advanced, recurrent or metastatic cutaneous squamous cell carcinoma

• Published in: Future oncology (London, England) England), 2022-06, Vol.18 (17), p.2087-2099
• Main Authors: Vo, Thao T, Espirito, Janet L, Boyd, Marley, Gumuscu, Burak, Chirovsky, Diana, Robert, Nicholas J, Swaby, Ramona F, Zhou, Wei, Cowey, Charles Lance
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Carboplatin; Carcinoma, Squamous Cell - pathology; Cetuximab - therapeutic use; cSCC; cutaneous squamous cell carcinoma; Female; Head and Neck Neoplasms - drug therapy; Humans; Male; metastatic; Neoplasm Recurrence, Local - drug therapy; outcomes; Paclitaxel; real-world; response; Skin Neoplasms - pathology
• ISSN: 1479-6694; 1744-8301
• DOI: 10.2217/fon-2021-1229

Real-world treatment patterns and clinical outcomes in advanced cutaneous squamous cell carcinoma were evaluated. Adults receiving their first systemic therapy for unresectable, locally advanced or recurrent/metastatic cutaneous squamous cell carcinoma from 4 September 2014 to 30 June 2017, were evaluated. The primary end point was real-world overall response rate per Response Evaluation Criteria in Solid Tumors or physician assessment. Time-to-event outcomes were assessed using the Kaplan–Meier method. Of 51 eligible patients, the median age was 76 years, 80% were male and 65% had an Eastern Cooperative Oncology Group score of 0–1. The most common regimens were cetuximab (51%) and carboplatin + paclitaxel (22%). Median real-world overall response rate ranged from 9.8% per Response Evaluation Criteria in Solid Tumors to 43.1% when supplemented by physician assessment. Median overall survival was 10.7 months, and median time to next treatment was 7.5 months. Survival in advanced cutaneous squamous cell carcinoma was short. Real-world overall response rate was lower with Response Evaluation Criteria in Solid Tumors than physician assessment. This study looked at chemotherapy treatments and responses in patients receiving treatment for advanced cutaneous squamous cell carcinoma, a type of skin cancer. Patients had advanced and metastatic cancer that could not be cured by radiation or surgery. Most of the patients were white males, and their median age was 76 years. About two-thirds of the patients in the study had their original cancer in the head and neck, and in most patients (approximately 80%), the cancer had spread, mostly to the lungs or lymph nodes. Half of the patients in the study were treated with cetuximab, and about a quarter received platinum chemotherapy or other cetuximab-based treatment. The study examined how response to treatment may be measured in clinical care and clinical trials. Response to treatment and length of survival were short: patients responded to treatment for a median of 9 months and survived for a median of 10.7 months.