Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway

Xuanfei Baidu Decoction (XFBD), one of the “three medicines and three prescriptions” for the clinically effective treatment of COVID-19 in China, plays an important role in the treatment of mild and/or common patients with dampness-toxin obstructing lung syndrome. The present work aims to elucidate...

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Bibliographic Details
Published in:	Journal of ethnopharmacology 2022-01, Vol.283 (NA), p.114701, Article 114701
Main Authors:	Wang, Yuying, Sang, Xiaoqing, Shao, Rui, Qin, Honglin, Chen, Xuanhao, Xue, Zhifeng, Li, Lin, Wang, Yu, Zhu, Yan, Chang, Yanxu, Gao, Xiumei, Zhang, Boli, Zhang, Han, Yang, Jian
Format:	Article
Language:	English
Subjects:	Animals Cell Survival - drug effects China collagen COVID-19 COVID-19 Drug Treatment COVID-19 infection Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use fibroblasts Fibroblasts - drug effects Gene Expression Regulation - drug effects Gene Regulatory Networks Humans IL-6/STAT3 inflammation Inflammation - drug therapy interleukin-4 interleukin-6 Interleukin-6 - antagonists & inhibitors Interleukin-6 - genetics Interleukin-6 - metabolism lungs Macrophage polarization macrophages Macrophages - drug effects Male Mice Mice, Inbred C57BL NIH 3T3 Cells Phytotherapy Pulmonary fibrosis Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control RAW 264.7 Cells SARS-CoV-2 Signal Transduction - drug effects STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism survival rate traditional medicine weight loss Xuanfei baidu decoction
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