Cue-induced craving and negative emotion disrupt response inhibition in methamphetamine use disorder: Behavioral and fMRI results from a mixed Go/No-Go task

Drug-related cue-reactivity, dysfunctional negative emotion processing, and response-disinhibition constitute three core aspects of methamphetamine use disorder (MUD). These phenomena have been studied independently, but the neuroscientific literature on their interaction in addictive disorders rema...

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Bibliographic Details
Published in:Drug and alcohol dependence 2022-04, Vol.233, p.109353-109353, Article 109353
Main Authors: Dakhili, Amirhossein, Sangchooli, Arshiya, Jafakesh, Sara, Zare-Bidoky, Mehran, Soleimani, Ghazaleh, Batouli, Seyed Amir Hossein, Kazemi, Kamran, Faghiri, Ashkan, Oghabian, Mohammad Ali, Ekhtiari, Hamed
Format: Article
Language:English
Subjects:
Addictions
Brain - diagnostic imaging
Cortex
Craving
Craving - physiology
Cue reactivity
Cues
Disinhibition
Drug abuse
Emotions
Errors
FMRI
Functional magnetic resonance imaging
Go/No-Go
Go/no-go discrimination learning
Humans
Inhibition
Inhibition (psychology)
Magnetic Resonance Imaging
Methamphetamine
Methamphetamine - adverse effects
Mud
Reaction time
Reactivity
Response inhibition
Temporal lobe
Visual cortex
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Summary:Drug-related cue-reactivity, dysfunctional negative emotion processing, and response-disinhibition constitute three core aspects of methamphetamine use disorder (MUD). These phenomena have been studied independently, but the neuroscientific literature on their interaction in addictive disorders remains scant. 62 individuals with MUD were scanned when responding to the geometric Go or No-Go cues superimposed over blank, neutral, negative-emotional and drug-related background images. Neural correlates of drug and negative-emotional cue-reactivity, response-inhibition and their interactions were estimated, and methamphetamine cue-reactivity was compared between individuals with MUD and 23 healthy controls. Relationships between behavioral characteristics and observed activations were investigated. Individuals with MUD had longer reaction times and more errors in drug and negative-emotional compared to blank blocks, and more omission errors in drug compared to neutral blocks. They showed higher drug cue-reactivity than controls across prefrontal, fusiform, and visual regions (Z > 3.1, p-corrected 3.1, p-corrected 3.1, p-corrected
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2022.109353