Splenectomy ameliorates portal pressure and anemia in animal models of cirrhotic and non-cirrhotic portal hypertension

Portal hypertension (PH)-associated splenomegaly is caused by portal venous congestion and splanchnic hyperemia. This can trigger hypersplenism, which favors the development of cytopenia. We investigated the time-dependent impact of splenectomy on portal pressure and blood cell counts in animal mode...

Full description

Saved in:
Bibliographic Details
Published in:Advances in medical sciences 2022-03, Vol.67 (1), p.154-162
Main Authors: Schwabl, Philipp, Seeland, Berit Anna, Riedl, Florian, Schubert, Tim Lukas, Königshofer, Philipp, Brusilovskaya, Ksenia, Petrenko, Oleksandr, Hofer, Benedikt, Schiefer, Ana-Iris, Trauner, Michael, Peck-Radosavljevic, Markus, Reiberger, Thomas
Format: Article
Language:English
Subjects:
Anemia - complications
Animals
Bile duct ligation
Cytopenia
Disease Models, Animal
Hypertension, Portal - complications
Ligation - adverse effects
Liver Cirrhosis - complications
Liver Cirrhosis - surgery
Partial portal vein ligation
Portal hypertension
Portal Pressure
Rats
Splenectomy
Splenectomy - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Portal hypertension (PH)-associated splenomegaly is caused by portal venous congestion and splanchnic hyperemia. This can trigger hypersplenism, which favors the development of cytopenia. We investigated the time-dependent impact of splenectomy on portal pressure and blood cell counts in animal models of non-cirrhotic and cirrhotic PH. Ninety-six rats underwent either partial portal vein ligation (PPVL), bile duct ligation (BDL), or sham operation (SO), with subgroups undergoing additional splenectomy. Portal pressure, mean arterial pressure, heart rate, blood cell counts and hemoglobin concentrations were evaluated throughout 5 weeks following surgery. Following PPVL or BDL surgery, the animals presented a progressive rise in portal pressure, paralleled by decreased mean arterial pressure and accelerated heart rate. Splenectomy curbed the development of PH in both models (PPVL: 16.25 vs. 17.93 ​mmHg, p ​= ​0.083; BDL: 13.55 vs. 15.23 ​mmHg, p ​= ​0.028), increased mean arterial pressure (PPVL: +7%; BDL: +9%), and reduced heart rate (PPVL: −10%; BDL: −13%). Accordingly, splenectomized rats had lower von Willebrand factor plasma levels (PPVL: −22%; BDL: −25%). Splenectomy resulted in higher hemoglobin levels in PPVL (14.15 vs. 13.08 ​g/dL, p ​
ISSN:1896-1126
1898-4002
DOI:10.1016/j.advms.2022.02.005