Effects of probiotics on gastric cancer‐related inflammation: A systematic review and meta‐analysis

• Published in: Journal of food biochemistry 2022-05, Vol.46 (5), p.e14034-n/a
• Main Authors: Yang, Dong, Meng, Xiang‐yu, Wang, Yue, Zhang, Jun, Zhao, Yan, Zheng, Zhi‐chao, Zhang, Tao
• Format: Article
• Language: English
• Subjects: gastric cancer; Humans; inflammation; Inflammation - drug therapy; Interleukin-6; meta‐analysis; Prebiotics; Probiotics; Randomized Controlled Trials as Topic; Stomach Neoplasms
• ISSN: 0145-8884; 1745-4514
• DOI: 10.1111/jfbc.14034

PubMed, ScienceDirect, Cochrane, Embase, Scopus, China National Knowledge Infrastructure (CNKI), Chinese Weipu, and Wanfang databases were searched to evaluate the effects of probiotics supplements on gastric cancer‐related inflammatory factors. Parallel randomized controlled trials (RCTs) assessing the effects of prebiotics supplement on gastric cancer patients were included in the review. Compared with routine nutrition, meta‐analysis shows that probiotics supplements reduce gastric cancer‐related inflammation levels by mostly increasing the levels of cluster of differentiation 4+ and greatly reducing the levels of interleukin‐6. Probiotics supplements can control the inflammatory response in cancer patients and may be a potential approach for controlling inflammatory levels in the patients. However, a larger population is needed for further study because of a certain degree of heterogeneity in this review. Practical applications The effects of probiotics (Bifidobacterium, Lactobacillus, and Streptococcus species) on the gastric cancer‐related inflammation were investigated. Probiotics can reduce gastric cancer‐related inflammation levels more effectively by increasing the levels of cluster of differentiation 4+ and greatly reducing the levels of interleukin‐6. The study provides some theoretical basis for controlling cancer‐related inflammation responses in the patients using probiotics. Probiotics diet (Bifidobacterium, Lactobacillus, and Streptococcus species) can affect the gastric cancer‐related inflammation. They reduce gastric cancer‐related inflammation levels more effectively by increasing the levels of albumin, prealbumin, CD4+ and CD8+ and reducing the levels of IL‐6, TNF alpha and CRP.