Biocompatible Inorganic Nanoagent for Efficient Synergistic Tumor Treatment with Augmented Antitumor Immunity

Synergistic therapy for malignant tumors has been developed in the past. However, several disadvantages that are associated with the applied inorganic nanoagents cannot be avoided, including intrinsic systemic toxicity, immunosuppression, and low therapeutic efficiency. Herein, a biocompatible, mult...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2022-04, Vol.18 (16), p.e2200897-n/a
Main Authors: Su, Juanjuan, Lu, Shuang, Wei, Zheng, Li, Bo, Li, Jingjing, Sun, Jing, Liu, Kai, Zhang, Hongjie, Wang, Fan
Format: Article
Language:English
Subjects:
antitumor immunity
Biocompatibility
cancer therapy
Cell Line, Tumor
chemodynamic performance
Erythrocytes
Glutathione
Glutathione - metabolism
Humans
Hydrogen peroxide
Hydroxyl Radical
Hydroxyl radicals
Immune system
Immunosuppression
inorganic nanoagents
Macrophages
Nanomaterials
Nanostructures
Nanotechnology
Neoplasms - drug therapy
photo‐thermal effects
Scavenging
Toxicity
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Summary:Synergistic therapy for malignant tumors has been developed in the past. However, several disadvantages that are associated with the applied inorganic nanoagents cannot be avoided, including intrinsic systemic toxicity, immunosuppression, and low therapeutic efficiency. Herein, a biocompatible, multifunctional, inorganic nanoagent that simultaneously integrates chemodynamic, starvation, and photothermal therapies is developed. This nanoagent effectively converts endogenous H2O2 into highly toxic hydroxyl radicals via the Fenton reaction. Self‐reinforced cancer therapy is achieved via the scavenging of intracellular glutathione and glucose. The encapsulation of nanoagent by erythrocytes drastically reduces its immune recognition by macrophages. Thus, an augmented anti‐tumor immune response is realized. Moreover, in contrast to traditional inorganic chemodynamic nanomaterials, the nanoagent has outstanding photothermal efficiency. Therefore, the present system exhibits an effective tumor therapeutic outcome. This work may facilitate a new pathway for the development of highly efficacious synergetic therapies. A type of multifunctional nanoagents with outstanding photothermal effects and superb chemodynamic performance is developed. In this system, the encapsulation of nanoagents by erythrocytes drastically reduces its immune recognition by macrophages. The augmented anti‐tumor immune response further promotes the effective therapy of deep‐tissue cancers.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202200897