EEG abnormalities and clinical phenotypes in pre-school children with autism spectrum disorder

•A Hight percentage of children with ASD shows abnormal electroencephalogram.•Abnormal EEG is related with impairment in executive function and social relationships.•Abnormal EEG in pre-school ASD children suggest worse development in clinical features. Abnormalities on electroencephalography (EEG)...

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Published in:Epilepsy & behavior 2022-04, Vol.129, p.108619-108619, Article 108619
Main Authors: Romero-González, Marina, Navas-Sánchez, Patricia, Marín-Gámez, Ester, Barbancho-Fernández, Miguel Angel, Fernández-Sánchez, Victoria Eugenia, Lara-Muñoz, José Pablo, Guzmán-Parra, José
Format: Article
Language:English
Subjects:
Autism spectrum disorder
Autism Spectrum Disorder - diagnosis
Child
Child, Preschool
Clinical features
Cross-Sectional Studies
EEG abnormalities
Electroencephalography - methods
Executive Function
Humans
Phenotype
Pre-school children
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Summary:•A Hight percentage of children with ASD shows abnormal electroencephalogram.•Abnormal EEG is related with impairment in executive function and social relationships.•Abnormal EEG in pre-school ASD children suggest worse development in clinical features. Abnormalities on electroencephalography (EEG) results have been reported in a high percentage of children with Autism Spectrum Disorder (ASD). The purpose of this study was to explore the prevalence of EEG abnormalities in a clinical population of pre-school children with Autism Spectrum Disorder and the differences in terms of the following phenotypic characteristics: adaptive behavior, executive functioning, severity of Autism Spectrum Disorder core symptoms, and comorbidity symptoms. A cross-sectional analysis of 69 children who attended the Autism Spectrum Disorder early diagnosis program with electroencephalography and clinical diagnosis was performed. A battery of questionnaires was also made to parents to evaluate emotions, behavior, and functional skills for daily living. Out of 69 pre-school children with Autism Spectrum Disorder, twenty nine (42%) had abnormalities in electroencephalography results. The group with abnormal epileptiform electroencephalography exhibited more impairment in executive functioning and social-relationship coexisting symptoms. The presence of an abnormal epileptiform electroencephalography in pre-school children with ASD already suggests a worse development in clinical features.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2022.108619