Evaluation of peripapillary and subfoveal choroidal vascularity index in patients with multiple sclerosis

•Peripapillary and sub-foveal choroidal tissue can be visualized using spectral-domain optical coherence tomography (OCT) in the EDI (enhanced depth imaging) mode.•It is possible to calculate the choroidal vascularity index utilizing a software program that separates the choroid into luminal and str...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2022-06, Vol.38, p.102810-102810, Article 102810
Main Authors: Garlı, Murat, Kurna, Sevda Aydın, Alış, Abdülkadir, Akın Çakır, Esra, Yükselen, Nihan Parasız, Açıkalın, Banu
Format: Article
Language:English
Subjects:
Multiple sclerosis
OCT
Optic neuritis
Optical Coherence Tomography
Peripapillary choroidal vascularity index
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Summary:•Peripapillary and sub-foveal choroidal tissue can be visualized using spectral-domain optical coherence tomography (OCT) in the EDI (enhanced depth imaging) mode.•It is possible to calculate the choroidal vascularity index utilizing a software program that separates the choroid into luminal and stromal areas with the method called binarization on EDI-OCT images.•To the extent of our knowledge, we investigated for the first time in the literature, the peripapillary choroidal vascularity index (PCVI) in patients with MS.•Our results revealed that PCVI and sub-foveal choroidal vascularity index (SFCVI) scores were significantly lower in MS patients compared to healthy controls. Besides, PCVI scores of MS patients who had a history of ON were significantly lower than those of patients without a previous ON attack, as were SFCVI scores.•Evaluation of PCVI and SFCVI might be useful for monitoring the vascular changes and ocular involvement in patients with MS. To evaluate the changes in the peripapillary choroidal vascularity index (PCVI) and subfoveal choroidal vascularity index (SFCVI) in multiple sclerosis (MS) patients and healthy subjects. A total of 145 eyes of 73 patients were investigated in this cross-sectional study. 78 eyes of 39 MS patients (Group 1) and 67 eyes of 34 healthy subjects (Group 2) were evaluated. MS patients with a history of optic neuritis (ON) constituted Group 1a, those without a history of ON constituted Group 1b. The mean PCVI was significantly lower in Group 1 than Group 2 (61,39 ± 3,00% vs 64,49 ± 2,29%, respectively, p 
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2022.102810