CD8+ T cells PUF(A)ing the flames of cancer ferroptotic cell death

In this issue of Cancer Cell, Liao et al. demonstrate that CD8+ T cell-secreted interferon-gamma (IFN-γ) rewires cancer cell lipid metabolism via the enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4). ACSL4 activates polyunsaturated fatty acids and sensitizes cancer cells to ferroptosis...

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Bibliographic Details
Published in:Cancer cell 2022-04, Vol.40 (4), p.346-348
Main Authors: Friedmann Angeli, José Pedro, Xavier da Silva, Thamara Nishida, Schilling, Bastian
Format: Article
Language:English
Subjects:
CD8-Positive T-Lymphocytes - metabolism
Cell Death
Coenzyme A Ligases - genetics
Coenzyme A Ligases - metabolism
Ferroptosis
Humans
Neoplasms
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Summary:In this issue of Cancer Cell, Liao et al. demonstrate that CD8+ T cell-secreted interferon-gamma (IFN-γ) rewires cancer cell lipid metabolism via the enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4). ACSL4 activates polyunsaturated fatty acids and sensitizes cancer cells to ferroptosis in immunotherapy-relevant settings. These findings provide insights into how the metabolic and immune milieu could be used to promote ferroptosis. In this issue of Cancer Cell, Liao et al. demonstrate that CD8+ T cell-secreted interferon-gamma (IFN-γ) rewires cancer cell lipid metabolism via the enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4). ACSL4 activates polyunsaturated fatty acids and sensitizes cancer cells to ferroptosis in immunotherapy-relevant settings. These findings provide insights into how the metabolic and immune milieu could be used to promote ferroptosis.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2022.03.003