Drug reaction with eosinophilia and systemic symptoms (DRESS): A tertiary care centre retrospective study

• Published in: British journal of clinical pharmacology 2022-09, Vol.88 (9), p.4134-4141
• Main Authors: Del Pozzo‐Magaña, Blanca R., Rieder, Michael J., Garcia‐Bournissen, Facundo, Lazo‐Langner, Alejandro
• Format: Article
• Language: English
• Subjects: adverse drug reaction; delayed hypersensitivity reaction; DRESS syndrome; drug reaction with eosinophilia and systemic symptoms
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1111/bcp.15354

Aims Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, drug‐induced severe adverse reaction that usually occurs 3–6 weeks after initial exposure to certain drugs. It affects mainly adults and children to a lesser extent. Clinical features include fever, facial oedema, generalized skin rash, lymphadenopathy, haematological abnormalities and internal organ involvement. The objective was to investigate the clinical and laboratory features of patients with DRESS in our centre. Methods We retrospectively describe and analyse 19 cases of DRESS whose diagnosis was based on the RegiSCAR criteria (≥6 points) that occurred from January 2009 to December 2019. Results Patient age ranged from 4 to 76 years (4 children/15 adults); 10 were female (52.3%). The most common culprit drugs were antibiotics (74%) and anticonvulsants (21%). The most common comorbidities were epilepsy (26%) and hypertension (26%). All patients developed cutaneous manifestations and of those, 58% presented facial oedema. Liver function tests, urea/creatinine and troponin elevation were present in 74, 32 and 42%, respectively. The median time to develop the skin rash after the drug exposure was 3.7 weeks (interquartile range 2.4–4.2 wk). Eosinophilia (≥0.7 × 109/L) was present in 95% of the patients and peaked around 10 days after the skin manifestations. Leucocytosis and reactive lymphocytes were reported in 84% and 26% of all patients respectively. Treatment with systemic steroids was reported in 16 patients. The mean recovery time was 2 weeks (interquartile range 2–3.5 wk) and mortality was 5%. Conclusion DRESS is a serious condition with significant morbidity and mortality, which requires more research for a better understanding.