Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB

The NF-κB essential modulator (NEMO) is a regulatory subunit of the IκB kinase (IKK) complex that phosphorylates the NF-κB inhibitors IκBs. NEMO mediates IKK activation by binding to polyubiquitin chains (polyUb). Here, we show that Lys63(K63)-linked or linear polyUb binding to NEMO robustly induced...

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Bibliographic Details
Published in:Molecular cell 2022-07, Vol.82 (13), p.2415-2426.e5
Main Authors: Du, Mingjian, Ea, Chee-Kwee, Fang, Yan, Chen, Zhijian J.
Format: Article
Language:English
Subjects:
Humans
I-kappa B Kinase - genetics
I-kappa B Kinase - metabolism
immunosuppression
liquids
NF-kappa B - metabolism
Polyubiquitin - genetics
separation
Signal Transduction
Ubiquitin - metabolism
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