Epstein–Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma

Endemic Burkitt lymphoma (eBL) is characterized by an oncogenic IGH/c‐MYC translocation and Epstein–Barr virus (EBV) positivity, and is epidemiologically linked to Plasmodium falciparum malaria. Both EBV and malaria are thought to contribute to eBL by inducing the expression of activation‐induced cy...

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Bibliographic Details
Published in:European journal of immunology 2022-08, Vol.52 (8), p.1273-1284
Main Authors: Summerauer, Andrea M., Jäggi, Vera, Ogwang, Rodney, Traxel, Sabrina, Colombo, Lorenzo, Amundsen, Eivind, Eyer, Tatjana, Subramanian, Bibin, Fehr, Jan, Mantel, Pierre‐Yves, Idro, Richard, Bürgler, Simone
Format: Article
Language:English
Subjects:
APOBEC
Apolipoprotein B
Burkitt lymphoma
Burkitt's lymphoma
Cytidine deaminase
Enzymes
Epidemiology
Epstein-Barr virus
Heavy chains
Immunoglobulins
Inoculation
Lymphocytes B
Lymphoma
Malaria
mRNA
mutagenesis
Myc protein
Plasmodium falciparum
RNA editing
Tumors
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