Serum Neurofilament Light Chain in Wilson's Disease: A Promising Indicator but Unparallel to Real‐Time Treatment Response

Background Wilson's disease (WD) currently lacks a promising indicator that could reflect neurological impairment and monitor treatment outcome. We aimed to investigate whether serum neurofilament light chain (sNfL) functions as a candidate for disease assessment and treatment monitoring of WD....

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Published in:Movement disorders 2022-07, Vol.37 (7), p.1531-1535
Main Authors: Wang, Rou‐Min, Xu, Wan‐Qing, Zheng, Zi‐Wei, Yang, Guo‐Min, Zhang, Mei‐Yan, Ke, Hua‐Zhen, Xia, Nan, Dong, Yi, Wu, Zhi‐Ying
Format: Article
Language:English
Subjects:
indicator
Magnetic resonance imaging
Movement disorders
neurofilament light chain
Neurological complications
neurological impairment
Parkinson's disease
Patients
treatment monitoring
Wilson's disease
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Summary:Background Wilson's disease (WD) currently lacks a promising indicator that could reflect neurological impairment and monitor treatment outcome. We aimed to investigate whether serum neurofilament light chain (sNfL) functions as a candidate for disease assessment and treatment monitoring of WD. Methods We assessed preclinical and manifested WD patients' sNfL levels compared to controls and analyzed the differences between patients with various clinical symptoms. We then explored the correlation between clinical scales and sNfL levels. And repeated measurements were performed in 34 patients before and after treatment. Results WD patients with neurological involvement had significantly higher sNfL levels than both hepatic patients and controls. Positive correlations were found between Unified Wilson's Disease Rating Scale scores and sNfL and between semiquantitative magnetic resonance imaging scales and sNfL levels in WD patients. However, in the treatment follow‐up analysis, the trend of sNfL before and after treatment disaccorded with clinical response. Conclusion These findings suggest that sNfL levels can be an ideal indicator for the severity of neurological involvement but fail to evaluate change in disease condition after treatment. © 2022 International Parkinson and Movement Disorder Society.
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.29039