Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage migh...

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Published in:	Cell 2022-03, Vol.185 (7), p.1189-1207.e25
Main Authors:	Nalio Ramos, Rodrigo, Missolo-Koussou, Yoann, Gerber-Ferder, Yohan, Bromley, Christian P., Bugatti, Mattia, Núñez, Nicolas Gonzalo, Tosello Boari, Jimena, Richer, Wilfrid, Menger, Laurie, Denizeau, Jordan, Sedlik, Christine, Caudana, Pamela, Kotsias, Fiorella, Niborski, Leticia L., Viel, Sophie, Bohec, Mylène, Lameiras, Sonia, Baulande, Sylvain, Lesage, Laëtitia, Nicolas, André, Meseure, Didier, Vincent-Salomon, Anne, Reyal, Fabien, Dutertre, Charles-Antoine, Ginhoux, Florent, Vimeux, Lene, Donnadieu, Emmanuel, Buttard, Bénédicte, Galon, Jérôme, Zelenay, Santiago, Vermi, William, Guermonprez, Pierre, Piaggio, Eliane, Helft, Julie
Format:	Article
Language:	English
Subjects:	Breast - immunology breast cancer breast neoplasms Breast Neoplasms - epidemiology Breast Neoplasms - immunology CD8+ T lymphocytes CD8-Positive T-Lymphocytes Female Folate Receptor 2 FOLR2 Humans immunity Lymphocytes, Tumor-Infiltrating Macrophages mammary glands neoplasm progression patients Prognosis single-cell RNA sequencing therapeutics tissue-resident macrophages TREM2
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