Nanomaterials in cancer: Reviewing the combination of hyperthermia and triggered chemotherapy

• Published in: Journal of controlled release 2022-07, Vol.347, p.89-103
• Main Authors: Ribeiro, Tiago P., Moreira, J. Agostinho, Monteiro, Fernando J., Laranjeira, Marta S.
• Format: Article
• Language: English
• Subjects: Cancer; Chemotherapy; Drug Release; Hyperthermia; Nanoparticles
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2022.04.045

Nanoparticle mediated hyperthermia has been explored as a method to increase cancer treatment efficacy by heating tumours inside-out. With that purpose, nanoparticles have been designed and their properties tailored to respond to external stimuli and convert the supplied energy into heat, therefore inducing damage to tumour cells. Moreover, the combination of hyperthermia with chemotherapy has been described as a more effective strategy due to the synergy between the high temperature and the drug’s effects, also associated with a remote controlled and on-demand drug release. In this review, the methods behind nanoparticle mediated hyperthermia, namely material design, external stimuli response and energy conversion will be discussed and critically analysed. We will address the most relevant studies on hyperthermia and temperature triggered drug release for cancer treatment. Finally, the advantages, difficulties and challenges of this therapeutic strategy will be discussed, while giving insight for future developments. [Display omitted] •Nanoparticles correct the non-specific mode of action of chemotherapy.•Hyperthermia works as an adjuvant in cancer therapy•Hyperthermia sensitizes cancer cells to chemotherapy.•Hyperthermia can be induced through several external stimuli.•Stimuli responsive nanomaterials allow for a remote-controlled drug release.