Significance of alveolar nitric oxide concentration in the airway of patients with organizing pneumonia after allogeneic hematopoietic stem cell transplantation

Organizing pneumonia (OP) is a complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a manifestation of peripheral airway/alveolar inflammation. Recently, alveolar nitric oxide concentration (Calv) has been revealed as a noninvasive marker of peripheral airway inflammati...

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Bibliographic Details
Published in:Annals of hematology 2022-08, Vol.101 (8), p.1803-1813
Main Authors: Kajimura, Yasuko, Nakamura, Yukinori, Hirano, Tsunahiko, Tanaka, Yoshinori, Yamamoto, Kaoru, Tokunaga, Yoshihiro, Sasaki, Takahiro, Oishi, Keiji, Yujiri, Toshiaki, Matsunaga, Kazuto, Tanizawa, Yukio
Format: Article
Language:English
Subjects:
Hematology
Medicine
Medicine & Public Health
Nitric oxide
Oncology
Original Article
Pneumonia
Stem cell transplantation
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Summary:Organizing pneumonia (OP) is a complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a manifestation of peripheral airway/alveolar inflammation. Recently, alveolar nitric oxide concentration (Calv) has been revealed as a noninvasive marker of peripheral airway inflammation; however, whether Calv levels are associated with OP and peripheral airway in patients after allo-HSCT remains unclear. Herein, we evaluated whether Calv levels could reflect the presence of OP and structural airway changes in patients after allo-HSCT. We measured the eNO levels of 38 patients (6 with OP and 32 without OP) who underwent allo-HSCT. Three-dimensional computed tomography (CT) analysis of the airway was performed in 19 patients. We found that in patients with OP, Calv levels were significantly higher than in those without OP (10.6 vs. 5.5 ppb, p  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-022-04868-x