Increased sedentary time and decreased physical activity increases lipoprotein associated phospholipase A2 in obese individuals

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2022-07, Vol.32 (7), p.1703-1710
• Main Authors: Clark, Kendall, Sharp, Sydney, Womack, Christopher J., Kurti, Stephanie P., Hargens, Trent A.
• Format: Article
• Language: English
• Subjects: Inflammation; Lipoprotein-associated phospholipase A2; Obesity; Physical activity; Sedentary
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2022.04.023

Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is a protein produced by inflammatory cells in circulation and is associated with cardiovascular disease (CVD) risk. Physical activity (PA) is known to reduce inflammation and risk for CVD. However, Lp-PLA2 has yet to be examined in relation to PA and sedentary time. The purpose of this study was to determine if PA and sedentary time impacts Lp-PLA2 mass. A total of 25 subjects with an average BMI of 30.6 ± 5.7 were included in the data analysis. Data collected included anthropometric data, Lp-PLA2 mass, peak oxygen uptake (VO2peak), resting heart rate and blood pressure, obstructive sleep apnea (OSA) risk, and assessment of PA using an accelerometer. Sedentary minutes per day was positively associated with Lp-PLA2 (r = 0.41, P < 0.05). Light intensity PA was negatively associated (r = −0.51. P = 0.01) with Lp-PLA2. When subjects were divided into 2-quantiles by Lp-PLA2, the group with the higher Lp-PLA2 mass accumulated more sedentary time per day (P < 0.001) and less light intensity PA per day (P = 0.001). OSA risk and Lp-PLA2 showed no relationship. Sedentary behavior was higher, and light intensity PA was lower in subjects with hiLp-PLA2 mass. No difference was seen in moderate-to-vigorous intensity PA or steps per day. This suggests that, total PA habits, including time spent sedentary and lower intensity PA, impacts the levels of Lp-PLA2, an important inflammatory marker and marker of CVD risk. •Lp-PLA2 was positively associated with the average number of sedentary minutes per day.•Lp-PLA2 was negatively associated with the average number of light intensity physical activity minutes per day.•In those with higher Lp-PLA2, a lower overall physical activity profile was reported.•Sedentary time, independent of physical activity, is an important factor in Lp-PLA2 mass in obese individuals.