Cryopreserved versus non-cryopreserved stem cell autografts in multiple myeloma a restrospective cohort study

The use of non-cryopreserved hematopoietic stem cells (HSC) can be an alternative to the traditional cryopreserved infusions of HSCs in autologous stem cell transplantation (aHSCT). After high-dose melphalan conditioning (HDM), we sought to compare time to engraftment, overall survival, and safety i...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2022-08, Vol.57 (8), p.1313-1318
Main Authors: Pessoa, Juliana Matos, da Rosa, Eurides Leite, Américo, André Dias, Motta, Camila Lucena, de Oliveira, Cleyton Zanardo, Concilio, Rosana Rocha, Amigo Filho, Jose Ulysses, Marret, Ana Cynira Franco, Lazar, Arlette Edna, De Gusmão, Breno Moreno, Scheinberg, Phillip, Kerbauy, Fábio Rodrigues
Format: Article
Language:English
Subjects:
13/100
692/308/2171
692/699/67/1990/804
Autografts
Bone marrow
Cell Biology
Cell viability
Cohort analysis
Conditioning
Cryopreservation
Drug dosages
Grafting
Hematology
Hematopoietic stem cells
Internal Medicine
Leukocytes (neutrophilic)
Medicine
Medicine & Public Health
Melphalan
Multiple myeloma
Patients
Public Health
Stem cell transplantation
Stem Cells
Transplantation
Transplants
Transplants & implants
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Summary:The use of non-cryopreserved hematopoietic stem cells (HSC) can be an alternative to the traditional cryopreserved infusions of HSCs in autologous stem cell transplantation (aHSCT). After high-dose melphalan conditioning (HDM), we sought to compare time to engraftment, overall survival, and safety in multiple myeloma (MM) patients undergoing a first aHSCT after high-dose melphalan conditioning (HDM). We conducted a cohort study from March 2018 to December 2019. Of all autologous transplants performed during this period, 105 were for MM as the first consolidation. Fifty-one patients received a cryopreserved graft; the remaining 54 patients received a fresh infusion. General clinical characteristics were similar between these two groups. Cell viability was higher in non-cryopreserved grafts (95% vs. 86% p  
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-022-01718-2