Mangosteen Inhibits Growth and Survival of Cervical Cancer Cells

Cervical cancer is the most common cancer of the female reproductive system. Late-stage cervical cancer treatment has been largely unsuccessful, and urgent anti-cancer therapy is needed. Mangosteen, a tropical fruit, has been studied and found to be rich in xanthones, known anti-cancer compounds. Th...

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Bibliographic Details
Published in:Anticancer research 2022-06, Vol.42 (6), p.2903-2909
Main Authors: Givens, Nathan T, Zhao, Lei, Zhu, Ziwen, Lequio, Marco, Xiao, Huaping, Johnson, Bradley D, Bai, Qian, Wakefield, Mark R, Fang, Yujiang
Format: Article
Language:English
Subjects:
Apoptosis
Biotin
Cancer immunotherapy
Caspase-3
Cell growth
Cell Line, Tumor
Cell Proliferation
Cell survival
Cervical cancer
Cervix
Cyclin B
Cyclin B - pharmacology
Cyclin D
Cyclin E
DNA nucleotidylexotransferase
Female
FLIP protein
Garcinia mangostana
Humans
Immunotherapy
Molecular modelling
Reproductive system
Statistical analysis
Survival
Survivin
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - genetics
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Summary:Cervical cancer is the most common cancer of the female reproductive system. Late-stage cervical cancer treatment has been largely unsuccessful, and urgent anti-cancer therapy is needed. Mangosteen, a tropical fruit, has been studied and found to be rich in xanthones, known anti-cancer compounds. This study was designed to investigate the effect of mangosteen extract (ME) on SiHa cervical cancer cells and to explore the underlying molecular mechanisms. Clonogenic survival assay, Quick Cell Proliferation Assay, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) staining, and caspase-3 activity kits were used to investigate the in vitro role of ME treatment in SiHa cervical cancer cell growth. We further investigated the possible molecular mechanisms using RT-PCR. Statistical analysis was done with unpaired two-tailed Student's t-test and significance at p-value
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15772