Control and Risk Factors of Nausea and Vomiting in Patients With Cervical Cancer Receiving Radiotherapy

Nausea and vomiting are two of the most distressing adverse events of cancer radiotherapy. The aim of this study was to examine the control rate and risk factors associated with nausea and vomiting in patients with cervical cancer receiving radiotherapy. This retrospective study examined patients wi...

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Bibliographic Details
Published in:Anticancer research 2022-06, Vol.42 (6), p.3117-3123
Main Authors: Uno, Akane, Yamamoto, Senri, Iihara, Hirotoshi, Fujii, Hironori, Makita, Chiyoko, Hayasaki, Yoh, Ueda, Yukino, Ito, Masaya, Takenaka, Motoki, Kumano, Tomoyasu, Mori, Minako, Yasue, Moeka, Kato-Hayashi, Hiroko, Kobayashi, Ryo, Morishige, Ken-Ichirou, Matsuo, Masayuki, Hayashi, Hideki, Suzuki, Akio
Format: Article
Language:English
Subjects:
Antiemetics
Antiemetics - therapeutic use
Antineoplastic Agents - therapeutic use
Cancer
Cervical cancer
Cervix
Cisplatin
Cisplatin - adverse effects
Dexamethasone
Dexamethasone - adverse effects
Female
Humans
Multivariate analysis
Nausea
Nausea - drug therapy
Nausea - etiology
Nausea - prevention & control
Neurokinin
Neurokinin NK1 receptors
Patients
Prophylaxis
Radiation therapy
Receptors
Regression analysis
Retrospective Studies
Risk analysis
Risk Factors
Risk management
Serotonin
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - radiotherapy
Vomiting
Vomiting - chemically induced
Vomiting - prevention & control
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Summary:Nausea and vomiting are two of the most distressing adverse events of cancer radiotherapy. The aim of this study was to examine the control rate and risk factors associated with nausea and vomiting in patients with cervical cancer receiving radiotherapy. This retrospective study examined patients with cervical cancer who received radiotherapy alone or with concomitant cisplatin. Patients who received radiotherapy alone were not administered antiemetic premedication, while patients who received radiotherapy with concomitant weekly cisplatin (40 mg/m ) were administered antiemetic therapy comprising granisetron and dexamethasone. Risk factors for non-complete response (CR) were identified using multivariate logistic regression analysis. Multivariate analysis indicated that younger age and concomitant weekly cisplatin were significant factors associated with non-CR across 5 weeks of treatment in patients who received radiotherapy. The proportion achieving CR among younger patients (
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15800