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Gender-specific impact of cognitive impairment on all-cause mortality in older persons: A meta-analysis
Gender-specific impact of cognitive impairment on survival in the general population remains controversial. The objective of this meta-analysis was to assess the gender difference in the impact of cognitive impairment on all-cause mortality in the general population. Two reviewers independently sear...
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Published in: | Experimental gerontology 2022-08, Vol.165, p.111860-111860, Article 111860 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Gender-specific impact of cognitive impairment on survival in the general population remains controversial. The objective of this meta-analysis was to assess the gender difference in the impact of cognitive impairment on all-cause mortality in the general population.
Two reviewers independently searched PubMed and Embase databases up to September 30, 2021 for cohort studies that reported gender-specific impact of cognitive impairment detected by the mini-mental state examination (MMSE) on all-cause mortality in elderly general population (aged ≥60 years) in the same study.
Nine articles reporting on 10 studies with a total of 52,134 individuals were included. The pooled multivariate-adjusted risk ratio (RR) of all-cause mortality associated with cognitive impairment compared with those without was 1.48 (95% confidence interval [CI] 1.36–1.61) in women and 1.34 (95% CI 1.24–1.44) in men, after adjusting for potential confounding. The pooled multivariate-adjusted female-to-male ratio of relative risk of all-cause mortality was 1.08 (95% CI 1.02–1.14) for individuals with cognitive impairment versus those without.
Cognitive impairment detected by the MMSE is associated with an increased risk of all-cause mortality in older aged women than in men from the general population, even after adjusting sociodemographic factors. Compared with men with cognitive impairment, women with cognitive impairment had an 8% higher risk of all-cause mortality. These findings highlight the importance of early detection and management of cognitive impairment in older adults, particularly in women.
•Impact of cognitive impairment on mortality in older persons differs between genders.•Older women with cognitive impairment had 48% higher risk of all-cause mortality.•Older men with cognitive impairment had 38% higher risk of all-cause mortality.•Older women with cognitive impairment conferring 8% higher risk of mortality than men•Early detection and management of cognitive impairment is important in older population. |
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ISSN: | 0531-5565 1873-6815 |
DOI: | 10.1016/j.exger.2022.111860 |