Correlation between oral fluid and blood THC concentration: A systematic review and discussion of policy implications

• Published in: Accident analysis and prevention 2022-08, Vol.173, p.106694-106694, Article 106694
• Main Authors: Robertson, M.B., Li, A., Yuan, Y., Jiang, A., Gjerde, H., Staples, J.A., Brubacher, J.R.
• Format: Article
• Language: English
• Subjects: Accidents, Traffic; Biomarkers; Blood; Cannabis; Dronabinol; Humans; Impaired driving; Marijuana; Oral fluid; Policy; Saliva - chemistry; Substance Abuse Detection; THC
• ISSN: 0001-4575; 1879-2057
• DOI: 10.1016/j.aap.2022.106694

•We reviewed research comparing oral fluid and blood THC concentrations.•We obtained THC concentrations from >18,000 paired samples of oral fluid and blood.•The presence of THC in oral fluid correlates well with its presence in blood.•Oral fluid THC, at commonly used cut-off values, is less sensitive and less specific as a biomarker for blood THC concentrations above commonly used per se limits.•Policy implications are discussed. Cannabis is the second most commonly used impairing substance by drivers, after alcohol. As more countries legalize cannabis, there is concern that cannabis-impaired driving will increase. In many countries, police use roadside devices to test for oral fluid THC (the primary psychotropic component in cannabis) to identify drivers who used cannabis; including in countries with non-zero per se limits for THC in blood. This practice is questioned as previous research demonstrates a poor correlation between oral fluid and blood THC concentrations at the individual level. We conducted a meta-analysis to identify all research that compared oral fluid with blood THC levels. We obtained individual-level data from study authors and analyzed pooled individual-level data to calculate sensitivity and specificity of oral fluid THC (at various cut-off values) to detect blood THC above different concentration limits. Finally, we explored practical implications of using oral fluid THC in an enforcement context. Our review found THC concentrations measured in over 18,000 paired samples of oral fluid and blood. We found a good correlation between the presence of THC in oral fluid and presence of THC in blood (sensitivity = 71.2%, specificity = 97.7%). However oral fluid THC, at commonly used cut-off values, is less sensitive and less specific when used as a biomarker to detect people with blood THC concentrations above commonly used per se limits (such as 5 ng/mL). As such, there will be a large number of “false positive” tests if oral fluid THC testing were used as a biomarker for “illegal” THC concentrations in randomly selected drivers. We argue that the adverse implications of false positive oral fluid THC tests in this context outweigh the possible road safety benefits and we recommend against oral fluid THC screening in randomly selected drivers in countries with non-zero per se limits for blood THC. In contrast, oral fluid THC tests appear to be useful for investigating “high-risk” drivers who come to police attention because of evidence of