Cadmium exposure and the risk of GDM: evidence emerging from the systematic review and meta-analysis

Gestational diabetes mellitus (GDM) has become a global concern for its severe adverse effects on both mother and fetus. Recent epidemiological studies reported inconsistent results of the association between cadmium (Cd) exposure and GDM. Therefore, a systematic review and meta- analysis were perfo...

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Bibliographic Details
Published in:Environmental science and pollution research international 2022-11, Vol.29 (51), p.77253-77274
Main Authors: Zhou, Minqi, Peng, Lianqi, Wang, Jingming, Cao, Rong, Ou, Zixuan, Fang, Yiwei
Format: Article
Language:English
Subjects:
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Cadmium
Criteria
Diabetes mellitus
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Epidemiology
Exposure
Fetuses
Heterogeneity
Meta-analysis
Observational studies
Outliers (statistics)
Research Article
Risk
Risk assessment
Statistical significance
Statistics
Subgroups
Systematic review
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Gestational diabetes mellitus (GDM) has become a global concern for its severe adverse effects on both mother and fetus. Recent epidemiological studies reported inconsistent results of the association between cadmium (Cd) exposure and GDM. Therefore, a systematic review and meta- analysis were performed. PubMed, Web of Science, Scopus, Embase, and SpringerLink were searched up to July 2021. Observational studies containing the adjusted relative risks between Cd exposure and GDM were included in the quantitative synthesis. The retrieval comprised 218 articles out of which 11 met our criteria and 9 were included in the meta-analysis, representing a total of 32,392 subjects (2881 GDM). In total, Cd exposure might increase the risk of GDM in some extent ( OR  = 1.21, 95% CI [0.89, 1.64]), even without statistical significance in high heterogeneity ( Q  = 28.45, p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-022-21171-4