A dataset resource for clinically associated phosphosites in hepatocellular carcinoma

Phosphorylation is one of the most common post‐translational modifications (PTMs) and is closely related to protein activity and function, playing a critical role during cancer development. Quantitative phosphoproteomic strategies have been widely used to study the underlying mechanisms of cancer pr...

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Bibliographic Details
Published in:Proteomics (Weinheim) 2023-02, Vol.23 (3-4), p.e2100407-n/a
Main Authors: Meng, Qian, Wang, Yuqiu, Lu, Dayun, Song, Nixue, Zhou, Hu, Zhu, Hongwen
Format: Article
Language:English
Subjects:
Biological activity
Carcinoma, Hepatocellular - pathology
Datasets
Drug resistance
Encyclopedias
Genomes
Hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - pathology
Metastases
Phosphorylation
phosphosites
Prognosis
Proteins
Rank tests
recurrence
Regression analysis
Statistical analysis
TNM stage
Variance analysis
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Summary:Phosphorylation is one of the most common post‐translational modifications (PTMs) and is closely related to protein activity and function, playing a critical role during cancer development. Quantitative phosphoproteomic strategies have been widely used to study the underlying mechanisms of cancer progression or drug resistance. In this report, we analyzed the association of phosphosite levels originated from our previously reported proteogenomic study in hepatocellular carcinoma (HCC) with clinical parameters, including prognosis, recurrence, and Tumor–Node–Metastasis (TNM) stages. By using both the log‐rank test and univariate Cox proportional hazards regression analysis, we found that the abundance levels of 1712 phosphosites were associated with prognosis and those of 393 phosphosites associated with recurrence. Besides, 692 phosphosites had different abundance levels among TNM stages (I, II, III+IV) by Analysis of Variance (ANOVA) test. Gene ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using proteins with these statistically significant phosphosites. In conclusion, we provided a dataset resource for clinically associated phosphosites in HCC, which may be beneficial to liver cancer related basic research.
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.202100407