Is there a sex gap in outcomes of comparable patients supported with left ventricular assist devices?

Objectives Historically, females were described as suffering from worse outcomes after left ventricular assist device (LVAD) implantation. However, females' preoperative conditions are unique, making direct comparisons with males challenging. This study aimed to select through propensity score...

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Bibliographic Details
Published in:Artificial organs 2022-11, Vol.46 (11), p.2293-2303
Main Authors: Li, Tong, Mariani, Silvia, Bounader, Karl, Boethig, Dietmar, Schöde, Alexandra, Homann, Katharina, Hanke, Jasmin S., Napp, L. Christian, Merzah, Ali Saad, Dogan, Guenes, Haverich, Axel, Schmitto, Jan D.
Format: Article
Language:English
Subjects:
Anticoagulants
Females
Heart
Heterogeneity
Implantation
left ventricular assist device
long‐term outcomes
Males
Matching
Patients
Sex
sex differences
Survival
Ventricle
Ventricular assist devices
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Summary:Objectives Historically, females were described as suffering from worse outcomes after left ventricular assist device (LVAD) implantation. However, females' preoperative conditions are unique, making direct comparisons with males challenging. This study aimed to select through propensity score (PS) matching two preoperatively comparable populations of females and males and test if any real sex‐related difference exists regarding survival and adverse events after LVAD implantation. Methods This retrospective single‐center observational study investigated patients who received LVAD implantation between 2010 and 2018. PS matching was applied to balance preoperative heterogeneity between males and females. Primary endpoint was survival at follow‐up. Secondary endpoints included perioperative outcomes and LVAD‐related adverse events. Results 92 fully comparable females(n = 46) and males(n = 46) were selected after PS matching (median age:57 years, min–max:18–75). 26.1% of patients required preoperative mechanical circulatory support. Females needed more intraoperative fresh frozen plasma (p 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.14333