Extracellular vesicles throughout development: A potential roadmap for emerging glioblastoma therapies

Extracellular vesicles (EVs) are membrane-delimited vesicular bodies carrying different molecules, classified according to their size, density, cargo, and origin. Research on this topic has been actively growing through the years, as EVs are associated with critical pathological processes such as ne...

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Published in:Seminars in cell & developmental biology 2023-01, Vol.133, p.32-41
Main Authors: Fernandes, Camila Felix de Lima, Coelho, Bárbara Paranhos, Souza, Maria Clara da Silva, Boccacino, Jacqueline Marcia, Soares, Samuel Ribeiro, Araújo, João Pedro Alves de, Melo-Escobar, Maria Isabel, Lopes, Marilene Hohmuth
Format: Article
Language:English
Subjects:
Cell Communication
Cell Differentiation
Embryonic development
Extracellular vesicles
Extracellular Vesicles - pathology
Glioblastoma
Glioblastoma - drug therapy
Glioblastoma - pathology
Glioblastoma stem cells
Humans
Neural stem cells
Stem Cells
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Summary:Extracellular vesicles (EVs) are membrane-delimited vesicular bodies carrying different molecules, classified according to their size, density, cargo, and origin. Research on this topic has been actively growing through the years, as EVs are associated with critical pathological processes such as neurodegenerative diseases and cancer. Despite that, studies exploring the physiological functions of EVs are sparse, with particular emphasis on their role in organismal development, initial cell differentiation, and morphogenesis. In this review, we explore the topic of EVs from a developmental perspective, discussing their role in the earliest cell-fate decisions and neural tissue morphogenesis. We focus on the function of EVs through development to highlight possible conserved or novel processes that can impact disease progression. Specifically, we take advantage of what was learned about their role in development so far to discuss EVs impact on glioblastoma, a particular brain tumor of stem-cell origin and poor prognosis, and how their function can be hijacked to improve current therapies. [Display omitted]
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2022.05.027