Efficacy of Oral vs. Intravenous Calcium Supplementation for Continuation Therapy in Hypocalcemic Seizures: A Randomized, Controlled Trial

Objective To evaluate efficacy of oral vs. intravenous calcium supplementation for continuation therapy in hypocalcemic seizures. Methods Sixty children between 1 mo and 5 y presenting with hypocalcemic seizures without any other underlying febrile, chronic systemic disease, or acute neurological il...

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Published in:Indian journal of pediatrics 2023-05, Vol.90 (5), p.433-437
Main Authors: Dhir, Himanshu, Kumar, Deepak, Shah, Dheeraj, Batra, Prerna, Ahmed, Rafat S., Gupta, Piyush
Format: Article
Language:English
Subjects:
Calcium
Calcium Gluconate
Child
Dietary Supplements
Gynecology
Humans
Hypocalcemia - drug therapy
Medicine
Medicine & Public Health
Original Article
Pediatrics
Seizures - drug therapy
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Summary:Objective To evaluate efficacy of oral vs. intravenous calcium supplementation for continuation therapy in hypocalcemic seizures. Methods Sixty children between 1 mo and 5 y presenting with hypocalcemic seizures without any other underlying febrile, chronic systemic disease, or acute neurological illness were included. Participants were randomized to receive either intravenous (IV) 10% calcium gluconate ( n  = 30) or oral elemental calcium ( n  = 30) for 48 h following initial seizure control with intravenous calcium. Results Seizures recurred in 3 (10%) children in IV group as compared to 4 (13.3%) in oral calcium group ( p  = 0.278) within 48 h. Serum calcium levels achieved in the two treatment groups at 24 h [7.96 (1.32) vs. 8.23 (1.58) mg/dL; p  = 0.476] and 48 h [8.5 (1.01) vs. 8.63 (1.39) mg/dL; p  = 0.681] were comparable. Conclusion Oral calcium may be as efficacious as intravenous calcium during continuation phase of treating hypocalcemic seizures; however, further studies are needed for definite recommendations. Trial Registration Trial Registration number: CTRI/2017/12/011042.
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-022-04178-0