Aging is associated with enhanced central but impaired peripheral arms of the sympathetic baroreflex arc

• Published in: Journal of applied physiology (1985) 2022-08, Vol.133 (2), p.349-360
• Main Authors: D’Souza, Andrew W., Klassen, Stephen A., Badrov, Mark B., Lalande, Sophie, Shoemaker, J. Kevin
• Format: Article
• Language: English
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00045.2022

The present study demonstrates for the first time that the spontaneous baroreflex threshold gains of integrated muscle sympathetic nerve activity burst occurrence and medium-sized action potential clusters are greater in older compared with young adults. Since sympathetic transduction was blunted in older compared with young adults, we interpret the data to indicate that the central arc of the baroreflex is enhanced in older adults to compensate for impairments in the peripheral arc. We tested the hypotheses that spontaneous baroreflex control of integrated muscle sympathetic nerve activity (MSNA) burst occurrence and action potential (AP) subpopulations would be blunted in older compared with young adults and that sympathetic transduction will be blunted in older adults relative to young adults. Integrated muscle sympathetic nerve activity (MSNA) and the underlying sympathetic APs were obtained using microneurography and a continuous wavelet analysis approach, respectively, during 5 min of supine rest in 13 older (45–75 yr, 6 females) and 14 young (21–30 yr, 7 females) adults. Baroreflex threshold relationships were quantified as the slope of the linear regression between MSNA burst occurrence (%) and diastolic blood pressure (mmHg), or AP cluster firing probability (%) and diastolic blood pressure (mmHg). Integrated MSNA baroreflex threshold gain was greater in older compared with young adults (older: −5.7 ± 2.6%/mmHg vs. young: −2.7 ± 1.4%/mmHg, P < 0.001). Similarly, the baroreflex threshold gain of AP clusters was modified by aging (group-by-cluster effect: P < 0.001) such that older adults demonstrated greater baroreflex threshold gains of medium-sized AP clusters (e.g., Cluster 4, older: −8.2 ± 3.2%/mmHg vs. young: −3.6 ± 1.9%/mmHg, P = 0.003) but not for the smallest-sized ( Cluster 1, older: −1.6 ± 1.9%/mmHg vs. young: −1.0 ± 1.7%/mmHg, P > 0.999) and largest-sized ( Cluster 10, older: −0.5 ± 0.5%/mmHg vs. young: −0.2 ± 0.1%/mmHg, P = 0.819) AP clusters compared with young adults. In contrast, the peak change in mean arterial pressure (MAP) following a spontaneous MSNA burst (i.e., sympathetic transduction) was impaired with aging (older: −0.7 ± 0.3 mmHg vs. young: 1.8 ± 1.2 mmHg, P < 0.001). We conclude that aging is associated with elevated baroreflex control over high-probability AP content of sympathetic bursts that may compensate for impaired sympathetic neurovascular transduction. NEW & NOTEWORTHY The present study demonstrates for the first