Cognitive reserve, neurocognitive performance, and high-order resting-state networks in cognitively unimpaired aging

•Cognitive reserve (CR) modulates resting-state networks in healthy older adults.•High CR is associated to increased Frontal-Parietal Control Network connectivity and reduced Dorsal Attention Network connectivity.•High CR connectivity pattern are associated to better cognitive performance. Cognitive...

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Published in:Neurobiology of aging 2022-09, Vol.117, p.151-164
Main Authors: Varela-López, Benxamín, Cruz-Gómez, Álvaro Javier, Lojo-Seoane, Cristina, Díaz, Fernando, Pereiro, A.X., Zurrón, Montserrat, Lindín, Mónica, Galdo-Álvarez, Santiago
Format: Article
Language:English
Subjects:
Cognitive reserve
DAN
FPCN
Healthy aging
Resting-state functional magnetic resonance
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Summary:•Cognitive reserve (CR) modulates resting-state networks in healthy older adults.•High CR is associated to increased Frontal-Parietal Control Network connectivity and reduced Dorsal Attention Network connectivity.•High CR connectivity pattern are associated to better cognitive performance. Cognitive Reserve (CR) is considered as one protective factor during the aging process. However, although CR is a multifactorial construct, it has been operationalized in a unitary way (years of formal education or IQ). In the present study, a validated measure to categorize CR holistically (Cognitive Reserve Index Questionnaire) was used to evaluate the resting-state functional connectivity in 77 cognitively unimpaired participants aged 50 years and over with high and low CR, and matched brain global atrophy levels. Specifically, the connectivity of networks linked to attentional (Dorsal Attention Network -DAN-) and executive (Frontal-Parietal Control Network -FPCN-) processes were evaluated by the combination of Independent Component Analysis and seed-based approaches, since these networks have been proposed as candidates to underlie the protective effect of CR in the aging context. Participants with high CR showed an increase of the connectivity in the FPCN and a decrease in the DAN with respect to the low CR group. These results correlated with neuropsychological scores and supported that high CR is related to a better neurocognitive preservation during aging.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2022.05.012