Associations Between the Lead Level in Maternal Blood and Umbilical Cord Blood and Congenital Heart Diseases in Offspring

The incidence of congenital heart diseases (CHDs) shows an increasing trend and results in large health burdens in China. However, there have been inconsistent results of the relationship between lead (Pb) level and risk of CHDs. We performed a pair-matched case–control study and included 97 cases a...

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Bibliographic Details
Published in:Biological trace element research 2023-05, Vol.201 (5), p.2191-2199
Main Authors: Huang, Lei, Mao, Baohong, Li, Jiayue, Nan, Nan, He, Li, Qiu, Jie, Yi, Bin, Liu, Qing
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biotechnology
Blood
Cardiovascular diseases
Case-Control Studies
Cohort Studies
Cohorts
Congenital diseases
Cord blood
Diseases
Female
Fetal Blood
Heart Defects, Congenital - epidemiology
Heart Defects, Congenital - etiology
Heart diseases
Humans
Lead
Life Sciences
Maternal Exposure - adverse effects
Nutrition
Offspring
Oncology
Pregnancy
Risk
Risk Factors
Umbilical cables
Umbilical cord
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Summary:The incidence of congenital heart diseases (CHDs) shows an increasing trend and results in large health burdens in China. However, there have been inconsistent results of the relationship between lead (Pb) level and risk of CHDs. We performed a pair-matched case–control study and included 97 cases and 194 controls to investigate the association between pregnancy Pb exposure and the risk of CHDs in a birth cohort study conducted in Lanzhou, China. The results showed that compared to the lowest Pb tertile, both highest tertile levels of maternal blood and umbilical cord blood Pb were associated with an increased risk of CHDs. The similar significant results were found in cases with isolated CHDs. Compared to both lowest tertiles of Pb level in maternal blood and umbilical cord blood, the highest tertile was associated with an increased risk of CHDs, especially for isolated CHDs. Overall, our study suggests a significant association between pregnancy Pb exposure and risk of CHDs, especially for isolated CHDs. Future studies are needed to elucidate the underlying mechanism.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-022-03338-9