Comparative efficiency of hematologic methods for determining procoagulant activity of biomedical materials

The interaction of blood with surfaces of medical devices can have various adverse effects, including thrombosis and thromboembolisms. To increase the blood-compatibility of medical devices, these adverse effects should be eliminated. Testing of procoagulant activity of biomaterials in vitro is perf...

Full description

Saved in:
Bibliographic Details
Published in:Biomedical engineering 1999-11, Vol.33 (6), p.288-292
Main Authors: Nemets, E. A., Sevast'yanov, V. I.
Format: Article
Language:English
Subjects:
Biomedical materials
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The interaction of blood with surfaces of medical devices can have various adverse effects, including thrombosis and thromboembolisms. To increase the blood-compatibility of medical devices, these adverse effects should be eliminated. Testing of procoagulant activity of biomaterials in vitro is performed using various modifications of conventional hematologic methods. These methods can be divided into three groups. The methods of the first group are based on the measurement of changes in the blood coagulation time caused by exposure to a foreign surface. The methods of the second groups are based on the measurement of the blood plasma recalcification time (BPRT) and activated partial thrombolplastin time (APTT). Methods of testing of biomaterial blood-compatibility in vitro belonging to the first and second groups are of particular interest. The methods of the third group are rather sophisticated and require expensive reagents. The goal of this work was to compare the efficiency of methods based on the measurement of BPRT and APTT for determining procoagulant activity of biomaterial surfaces brought into contact with blood plasma.
ISSN:0006-3398
1573-8256
DOI:10.1007/BF02385388