Effects of postnatal hydrocortisone on cytokine profile in extremely preterm infants

Background Systemic hydrocortisone administration has been widely used in preterm infants who are at risk of bronchopulmonary dysplasia (BPD). However, the effects of hydrocortisone on cytokine profiles have not been examined. We aimed to investigate the effects of postnatal hydrocortisone treatment...

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Published in:Pediatrics international 2022-01, Vol.64 (1), p.e15205-n/a
Main Authors: Tamura, Kentaro, Nagaoka, Mitsuhide, Inomata, Satomi, Kawasaki, Yukako, Makimoto, Masami, Yoshida, Taketoshi
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Language:English
Subjects:
bronchopulmonary dysplasia
Chemokines
cytokine
Cytokines
Gestational age
Helper cells
Hydrocortisone
Infants
Inflammation
Interleukin 6
Lymphocytes T
Neonates
Newborn babies
Pediatrics
Premature babies
preterm infant
Steroids
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container_title Pediatrics international
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Nagaoka, Mitsuhide
Inomata, Satomi
Kawasaki, Yukako
Makimoto, Masami
Yoshida, Taketoshi
description Background Systemic hydrocortisone administration has been widely used in preterm infants who are at risk of bronchopulmonary dysplasia (BPD). However, the effects of hydrocortisone on cytokine profiles have not been examined. We aimed to investigate the effects of postnatal hydrocortisone treatment on serum cytokine levels in extremely preterm infants. Methods This is a retrospective study of 29 extremely preterm infants born at
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However, the effects of hydrocortisone on cytokine profiles have not been examined. We aimed to investigate the effects of postnatal hydrocortisone treatment on serum cytokine levels in extremely preterm infants. Methods This is a retrospective study of 29 extremely preterm infants born at &lt;28 weeks of gestational age. We obtained serum from blood samples collected during an early phase (5–20 days) and a late phase (28–60 days) after birth. We measured the levels of proinflammatory cytokines (tumor necrosis factors α and β, interleukin (IL)‐1β, and IL‐6), T‐helper (Th) 1 cytokines (interferon‐γ, IL‐2, and IL‐12p70), Th2 cytokines (IL‐4, IL‐5, and IL‐10), Th17 cytokine IL‐17A, and chemokine IL‐8. The cytokine levels between the early and late phases were compared between infants who received postnatal hydrocortisone and those who did not. Results Thirteen infants (45%) received systemic hydrocortisone treatment at a median age of 15 days (IQR: 10.0–21.5) after birth due to respiratory deterioration. The percentage of BPD was higher in the steroid group than in the non‐steroid group (P = 0.008). The ratio of IL‐6 for the late‐to‐early phase was significantly lower in the steroid group than in the non‐steroid group (P = 0.04). The concentration of the other cytokines remained unchanged between the phases. Conclusions Although the postnatal hydrocortisone treatment provided for respiratory deterioration did not prevent the BPD development, hydrocortisone treatment might suppress IL‐6 overproduction in extremely preterm infants.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.15205</identifier><language>eng</language><publisher>Tokyo: Blackwell Publishing Ltd</publisher><subject>bronchopulmonary dysplasia ; Chemokines ; cytokine ; Cytokines ; Gestational age ; Helper cells ; Hydrocortisone ; Infants ; Inflammation ; Interleukin 6 ; Lymphocytes T ; Neonates ; Newborn babies ; Pediatrics ; Premature babies ; preterm infant ; Steroids</subject><ispartof>Pediatrics international, 2022-01, Vol.64 (1), p.e15205-n/a</ispartof><rights>2022 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3805-d00cc0bfa7a73f2205b9d5b9f06e879b20a9134dfeaea417cf209ef86987b70f3</cites><orcidid>0000-0002-9937-1703 ; 0000-0002-0418-9985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Tamura, Kentaro</creatorcontrib><creatorcontrib>Nagaoka, Mitsuhide</creatorcontrib><creatorcontrib>Inomata, Satomi</creatorcontrib><creatorcontrib>Kawasaki, Yukako</creatorcontrib><creatorcontrib>Makimoto, Masami</creatorcontrib><creatorcontrib>Yoshida, Taketoshi</creatorcontrib><title>Effects of postnatal hydrocortisone on cytokine profile in extremely preterm infants</title><title>Pediatrics international</title><description>Background Systemic hydrocortisone administration has been widely used in preterm infants who are at risk of bronchopulmonary dysplasia (BPD). However, the effects of hydrocortisone on cytokine profiles have not been examined. We aimed to investigate the effects of postnatal hydrocortisone treatment on serum cytokine levels in extremely preterm infants. Methods This is a retrospective study of 29 extremely preterm infants born at &lt;28 weeks of gestational age. We obtained serum from blood samples collected during an early phase (5–20 days) and a late phase (28–60 days) after birth. We measured the levels of proinflammatory cytokines (tumor necrosis factors α and β, interleukin (IL)‐1β, and IL‐6), T‐helper (Th) 1 cytokines (interferon‐γ, IL‐2, and IL‐12p70), Th2 cytokines (IL‐4, IL‐5, and IL‐10), Th17 cytokine IL‐17A, and chemokine IL‐8. The cytokine levels between the early and late phases were compared between infants who received postnatal hydrocortisone and those who did not. Results Thirteen infants (45%) received systemic hydrocortisone treatment at a median age of 15 days (IQR: 10.0–21.5) after birth due to respiratory deterioration. The percentage of BPD was higher in the steroid group than in the non‐steroid group (P = 0.008). The ratio of IL‐6 for the late‐to‐early phase was significantly lower in the steroid group than in the non‐steroid group (P = 0.04). The concentration of the other cytokines remained unchanged between the phases. Conclusions Although the postnatal hydrocortisone treatment provided for respiratory deterioration did not prevent the BPD development, hydrocortisone treatment might suppress IL‐6 overproduction in extremely preterm infants.</description><subject>bronchopulmonary dysplasia</subject><subject>Chemokines</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Gestational age</subject><subject>Helper cells</subject><subject>Hydrocortisone</subject><subject>Infants</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Lymphocytes T</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Pediatrics</subject><subject>Premature babies</subject><subject>preterm infant</subject><subject>Steroids</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LxDAQhoMouK4e_AcFL3ro7jT9So6yrh-woIcVvIU0nWDXtqlJFu2_N1pPggPDvAzPDC8vIecJLJJQywHrRZJTyA_ILMkyGlOAl8OgU8piBkV5TE6c2wEAK1k2I9u11qi8i4yOBuN8L71so9extkYZ6xtneoxMH6nRm7cm6MEa3bQYNX2En95ih-0YlujRdmGpZe_dKTnSsnV49jvn5Pl2vV3dx5vHu4fV9SZWKYM8rgGUgkrLUpappsF0xevQGgpkJa8oSJ6kWa1RosySUmkKHDUrOCurEnQ6J5fT32DqfY_Oi65xCttW9mj2TtCC8aJgDNKAXvxBd2Zv--BOUMYhZZzl39TVRClrnLOoxWCbTtpRJCC-8xUhX_GTb2CXE_sR4hj_B8XT-ma6-AI3xX02</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Tamura, Kentaro</creator><creator>Nagaoka, Mitsuhide</creator><creator>Inomata, Satomi</creator><creator>Kawasaki, Yukako</creator><creator>Makimoto, Masami</creator><creator>Yoshida, Taketoshi</creator><general>Blackwell Publishing Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9937-1703</orcidid><orcidid>https://orcid.org/0000-0002-0418-9985</orcidid></search><sort><creationdate>202201</creationdate><title>Effects of postnatal hydrocortisone on cytokine profile in extremely preterm infants</title><author>Tamura, Kentaro ; Nagaoka, Mitsuhide ; Inomata, Satomi ; Kawasaki, Yukako ; Makimoto, Masami ; Yoshida, Taketoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3805-d00cc0bfa7a73f2205b9d5b9f06e879b20a9134dfeaea417cf209ef86987b70f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>bronchopulmonary dysplasia</topic><topic>Chemokines</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Gestational age</topic><topic>Helper cells</topic><topic>Hydrocortisone</topic><topic>Infants</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Lymphocytes T</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Pediatrics</topic><topic>Premature babies</topic><topic>preterm infant</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamura, Kentaro</creatorcontrib><creatorcontrib>Nagaoka, Mitsuhide</creatorcontrib><creatorcontrib>Inomata, Satomi</creatorcontrib><creatorcontrib>Kawasaki, Yukako</creatorcontrib><creatorcontrib>Makimoto, Masami</creatorcontrib><creatorcontrib>Yoshida, Taketoshi</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamura, Kentaro</au><au>Nagaoka, Mitsuhide</au><au>Inomata, Satomi</au><au>Kawasaki, Yukako</au><au>Makimoto, Masami</au><au>Yoshida, Taketoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of postnatal hydrocortisone on cytokine profile in extremely preterm infants</atitle><jtitle>Pediatrics international</jtitle><date>2022-01</date><risdate>2022</risdate><volume>64</volume><issue>1</issue><spage>e15205</spage><epage>n/a</epage><pages>e15205-n/a</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background Systemic hydrocortisone administration has been widely used in preterm infants who are at risk of bronchopulmonary dysplasia (BPD). However, the effects of hydrocortisone on cytokine profiles have not been examined. We aimed to investigate the effects of postnatal hydrocortisone treatment on serum cytokine levels in extremely preterm infants. Methods This is a retrospective study of 29 extremely preterm infants born at &lt;28 weeks of gestational age. We obtained serum from blood samples collected during an early phase (5–20 days) and a late phase (28–60 days) after birth. We measured the levels of proinflammatory cytokines (tumor necrosis factors α and β, interleukin (IL)‐1β, and IL‐6), T‐helper (Th) 1 cytokines (interferon‐γ, IL‐2, and IL‐12p70), Th2 cytokines (IL‐4, IL‐5, and IL‐10), Th17 cytokine IL‐17A, and chemokine IL‐8. The cytokine levels between the early and late phases were compared between infants who received postnatal hydrocortisone and those who did not. Results Thirteen infants (45%) received systemic hydrocortisone treatment at a median age of 15 days (IQR: 10.0–21.5) after birth due to respiratory deterioration. The percentage of BPD was higher in the steroid group than in the non‐steroid group (P = 0.008). The ratio of IL‐6 for the late‐to‐early phase was significantly lower in the steroid group than in the non‐steroid group (P = 0.04). The concentration of the other cytokines remained unchanged between the phases. Conclusions Although the postnatal hydrocortisone treatment provided for respiratory deterioration did not prevent the BPD development, hydrocortisone treatment might suppress IL‐6 overproduction in extremely preterm infants.</abstract><cop>Tokyo</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1111/ped.15205</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9937-1703</orcidid><orcidid>https://orcid.org/0000-0002-0418-9985</orcidid></addata></record>
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source Wiley-Blackwell Read & Publish Collection
subjects bronchopulmonary dysplasia
Chemokines
cytokine
Cytokines
Gestational age
Helper cells
Hydrocortisone
Infants
Inflammation
Interleukin 6
Lymphocytes T
Neonates
Newborn babies
Pediatrics
Premature babies
preterm infant
Steroids
title Effects of postnatal hydrocortisone on cytokine profile in extremely preterm infants
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