Age-related Mitochondrial Dysfunction in Parkinson's Disease: New Insights Into the Disease Pathology

• Published in: Neuroscience 2022-09, Vol.499, p.152-169
• Main Authors: Rani, Linchi, Sahu, Manas Ranjan, Mondal, Amal Chandra
• Format: Article
• Language: English
• Subjects: Aging; Mitochondrial aberrations; Mitochondrial quality control mechanism; Parkinson’s disease
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2022.07.007

[Display omitted] •Many physiological processes affected in PD are linked to aging.•Aging alters complex mitochondrial homeostasis.•Several mitochondrial changes overlap with aging and PD.•Age-related disruption of mitochondrial quality control contributes to PD pathology. Aging is a progressive loss of physiological function that increases risk of disease and death. Among the many factors that contribute to human aging, mitochondrial dysfunction has emerged as one of the most prominent features of the aging process. It has been linked to the development of various age-related pathologies, including Parkinson's disease (PD). Mitochondria has a complex quality control system that ensures mitochondrial integrity and function. Perturbations in these mitochondrial mechanisms have long been linked to various age-related neurological disorders. Even though research has shed light on several aspects of the disease pathology, the underlying mechanism of age-related factors responsible for individuals developing this disease is still unknown. This review article aims to discuss the role of mitochondria in the transition from normal brain aging to pathological brain aging, which leads to the progression of PD. We have discussed the emerging evidence on how age-related disruption of mitochondrial quality control mechanisms contributes to the development of PD-related pathophysiology.