Association between thyroid function and comorbid anxiety in first-episode and drug naïve patients with major depressive disorder

Objective Existing studies have shown that thyroid dysfunction is associated with depression. However, its role in major depressive disorder (MDD) with comorbid anxiety remains unclear. The main purpose of this study was to compare thyroid function in a large sample of first episode drug naïve (FEDN...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2023-02, Vol.273 (1), p.191-198
Main Authors: Yang, Wanqiu, Qu, Miao, Jiang, Rui, Lang, XiaoE, Zhang, Xiang-Yang
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Anxiety
Anxiety disorders
Comorbidity
Diagnosis
Drug therapy
Iodide peroxidase
Major depressive disorder
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Mental depression
Neurosciences
Original Paper
Patients
Psychiatry
Psychosis
Serum levels
Suicide
Thyroglobulin
Thyroid
Thyroid diseases
Thyroid gland
Thyroid hormones
Thyroid-stimulating hormone
Thyrotropin
Thyroxine
Triiodothyronine
Viral antibodies
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Summary:Objective Existing studies have shown that thyroid dysfunction is associated with depression. However, its role in major depressive disorder (MDD) with comorbid anxiety remains unclear. The main purpose of this study was to compare thyroid function in a large sample of first episode drug naïve (FEDN) MDD patients with and without anxiety. Methods This cross-sectional study examined 1718 outpatients who were drug-naïve and diagnosed as MDD at first episode. Socio-demographic and clinical data, as well as thyroid function-related parameters, including free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb) and anti-thyroglobulin (TGAb), were evaluated. The Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA) and the positive subscale of the Positive and Negative Syndrome Scale (PANSS) were used to evaluate depressive, anxiety and psychotic symptoms, respectively. Results Compared to MDD patients without anxiety, MDD patients with anxiety were more likely to have more suicide attempts and psychotic symptoms, as well as higher serum levels of TSH, TPOAb and TGAb (all p  
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-022-01457-x