Surgery for maxillary oral squamous cell carcinoma: the effect of surgical resection margins and elective neck dissection on oncological outcomes

• Published in: International journal of oral and maxillofacial surgery 2023-03, Vol.52 (3), p.283-290
• Main Authors: Woo, S., DeAngelis, A., Koo, K., Kranz, S., Nastri, A., Iseli, T.A., Fua, T., Wiesenfeld, D.
• Format: Article
• Language: English
• Subjects: Carcinoma, Squamous Cell - pathology; Head and neck cancer; Head and Neck Neoplasms - surgery; Humans; Margins of Excision; Maxilla; Mouth Neoplasms - pathology; Mouth Neoplasms - surgery; Neck Dissection; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Oral cancer; Oral squamous cell carcinoma; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck - surgery; Surgical margins
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/j.ijom.2022.06.015

Maxillary oral squamous cell carcinoma (OSCC) is uncommon. Surgical resection is challenging due to the anatomy, and the role of elective neck dissection (END) is not well-defined. A retrospective cohort study of patients with maxillary OSCC treated with primary surgery between 2007 and 2019 was conducted. Primary tumours of sinonasal origin with extension into the oral cavity were excluded. Survival analysis was performed using Kaplan–Meier and Cox proportional hazards models. Sixty-seven patients were included; mean follow-up was 55 months. On univariate analysis, clear (≥5 mm) margins were associated with higher disease-free (68% vs 36%, P = 0.019) and overall survival (75% vs 36%, P = 0.004) than close/involved (