Engineering Hydrogels for Modulation of Material‐Cell Interactions

Hydrogels are a recurrent platform for Tissue Engineering (TE) strategies. Their versatility and the variety of available methods for tuning their properties highly contribute to hydrogels’ success. As a result, the design of advanced hydrogels has been thoroughly studied, in the quest for better so...

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Bibliographic Details
Published in:Macromolecular bioscience 2022-10, Vol.22 (10), p.e2200091-n/a
Main Authors: Vieira, Sílvia, Silva‐Correia, Joana, Reis, Rui L., Oliveira, J. Miguel
Format: Article
Language:English
Subjects:
Biomaterials
Biomedical materials
Cell interactions
Crosslinking
Extracellular matrix
Hydrogels
Information processing
material‐cell interactions
Tissue engineering
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Summary:Hydrogels are a recurrent platform for Tissue Engineering (TE) strategies. Their versatility and the variety of available methods for tuning their properties highly contribute to hydrogels’ success. As a result, the design of advanced hydrogels has been thoroughly studied, in the quest for better solutions not only for drugs‐ and cell‐based therapies but also for more fundamental studies. The wide variety of sources, crosslinking strategies, and functionalization methods, and mostly the resemblance of hydrogels to the natural extracellular matrix, makes these three dimensional hydrated structures an excellent tool for TE approaches. The state‐of‐the‐art information regarding hydrogel design, processing methods, and the influence of different hydrogel formulations on the final cell‐biomaterial interactions are overviewed herein. Due to their versatility and tuneability, hydrogels are a recurrent platform for Tissue Engineering strategies. The development of advanced hydrogels has been thoroughly investigated whether envisioning their application for drugs‐ and cell‐based therapies or for more fundamental studies. This review discusses the new developments in hydrogel design, processing methods, and the influence of the different hydrogel properties on material‐cell interactions.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.202200091