Impact of CPAP on the Atrial Fibrillation Substrate in Obstructive Sleep Apnea: The SLEEP-AF Study

BACKGROUNDObservational studies report that obstructive sleep apnea (OSA) is associated with an increasingly remodeled atrial substrate in atrial fibrillation (AF). However, the impact of OSA management on the electrophysiologic substrate has not been evaluated. OBJECTIVESIn this study, the authors...

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Published in:JACC. Clinical electrophysiology 2022-07, Vol.8 (7), p.869-877
Main Authors: Nalliah, Chrishan J, Wong, Geoffrey R, Lee, Geoffrey, Voskoboinik, Aleksandr, Kee, Kirk, Goldin, Jeremy, Watts, Troy, Linz, Dominik, Parameswaran, Ramanathan, Sugumar, Hariharan, Prabhu, Sandeep, McLellan, Alex, Ling, Liang-Han, Joseph, Stephen A, Morton, Joseph B, Kistler, Peter, Sanders, Prashanthan, Kalman, Jonathan M
Format: Article
Language:English
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Summary:BACKGROUNDObservational studies report that obstructive sleep apnea (OSA) is associated with an increasingly remodeled atrial substrate in atrial fibrillation (AF). However, the impact of OSA management on the electrophysiologic substrate has not been evaluated. OBJECTIVESIn this study, the authors sought to determine the impact of OSA management on the atrial substrate in AF. METHODSWe recruited 24 consecutive patients referred for AF management with at least moderate OSA (apnea-hypopnea index [AHI] ≥15). Participants were randomized in a 1:1 ratio to commence continuous positive airway pressure (CPAP) or no therapy (n = 12 CPAP; n = 12 no CPAP). All participants underwent invasive electrophysiologic study (high-density right atrial mapping) at baseline and after a minimum of 6 months. Outcome variables were atrial voltage (mV), conduction velocity (m/s), atrial surface area
ISSN:2405-5018
DOI:10.1016/j.jacep.2022.04.015