Self‐Assembly Anchored Cationic Copolymer Interfaces for Applying the Control of Counterion‐Induced Bacteria Killing/Release Procedure

• Published in: Macromolecular bioscience 2022-11, Vol.22 (11), p.e2200207-n/a
• Main Authors: Chiu, Chieh‐Yang, Lin, Hao‐Tung, Yen, Ta‐Jen, Chang, Yung
• Format: Article
• Language: English
• Subjects: Amines; Bacteria; bacterial killing/release procedure; Benzene; Biomaterials; Biomedical materials; cationic copolymer interfaces; Cations; Copolymers; counterion‐induced self‐cleaning; Disease control; Epidemics; Hydrophobicity; Hygiene; Interfaces; Macromolecules; polycationic interface; Polymers; Polymers - chemistry; Polymers - pharmacology; Polystyrene; Polystyrene resins; Quaternary ammonium salts; Ring structures; self‐assembly anchoring; Substrates; Viruses
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.202200207

In recent years, daily hygiene and disease control issues have received increasing attention, especially the raging epidemics caused by the spread of deadly viruses. The construction of the interface of new polymer materials is focused on, which can provide a cyclic operation process for the killing and releasing of bacteria, and perform repeated regeneration, which is of great significance for the development of advanced medical biomaterials. In order to explore the basic physical phenomena of bacterial attachment and detachment on the polymer material interface by different amine groups, this study plans to synthesize four different butyl methacrylate (BMA)‐based cationic copolymers with primary, ternary, and quaternary amine groups, and compare their effects on bactericidal efficiency. Since BMA can generate strong hydrophobic interactions with the benzene ring structure, this study used a polystyrene substrate to realize a self‐assembled cationic copolymer interface for controlling the counterion‐induced bacterial killing/release process. Furthermore, negatively charged ions are introduced to induce changes in the hydration capability of water molecules and control the subsequent bacterial detachment function. In this study, possible directions to answer and clarify the above concepts are proposed, and there is a basic reference principle that can lead to research work in macromolecular bioscience fields. This study focuses on the construction of new polycationic materials, which can provide a cyclic operation process for the killing and releasing of bacteria, and perform repeated regeneration, which is of great significance for the development of advanced medical biomaterials. The results perform a self‐assembled cationic copolymer interface for controlling the counterion‐induced bacterial killing/release process.