Prophylactic administration of HPA-1a–specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice

•A novel alloantigen-specific model has been developed and used to examine the efficacy of a prophylactic treatment regimen for FNAIT.•The resulting preclinical data provide guidance for the use of HPA-1a–specific antibodies to prevent FNAIT in humans. [Display omitted] Fetal/neonatal alloimmune thr...

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Bibliographic Details
Published in:Blood 2022-11, Vol.140 (20), p.2146-2153
Main Authors: Zhi, Huiying, Sheridan, Douglas, Newman, Debra K., Newman, Peter J.
Format: Article
Language:English
Subjects:
Animals
Antigens, Human Platelet
Female
Fetus
Humans
Integrin beta3
Isoantibodies
Mice
Pregnancy
Prenatal Care
Thrombocytopenia, Neonatal Alloimmune - prevention & control
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