Pelvic organ prolapse recurrence after pregnancy following uterine-sparing prolapse repair: a systematic review and meta-analysis

• Published in: International Urogynecology Journal 2023-02, Vol.34 (2), p.345-356
• Main Authors: Andebrhan, Sarah B., Caron, Ashley T., Szlachta-McGinn, Alec, Parameshwar, Pooja S., Jackson, Nicholas J., Rosenman, Amy E., Anger, Jennifer T., Ackerman, A. Lenore
• Format: Article
• Language: English
• Subjects: Abdomen; Cesarean Section; Childbirth & labor; Female; Gynecologic Surgical Procedures - methods; Gynecology; Humans; Laparoscopy; Medicine; Medicine & Public Health; Meta-analysis; Pelvic organ prolapse; Pelvic Organ Prolapse - surgery; Pregnancy; Review Article; Surgical Mesh; Systematic review; Treatment Outcome; Urology; Uterine Prolapse - surgery; Uterus; Vagina
• ISSN: 0937-3462; 1433-3023
• DOI: 10.1007/s00192-022-05306-2

Introduction We sought to determine rates of pelvic organ prolapse (POP) recurrence following pregnancy and delivery in reproductive-age women with prior hysteropexy. Methods Scopus, MEDLine, EMBASE, Cochrane Library, and ClinicalTrials.gov databases were searched from inception to May 2020 for combinations of any of the keywords: “pregnancy”, “delivery”, “fertility”, or “cesarean” with a comprehensive list of uterine-sparing surgical procedures for POP repair. Using approach, 1,817 articles were identified describing surgical, uterine-sparing POP repair techniques and subsequent pregnancy and delivery outcomes in reproductive-age women.   Results Twenty-seven studies describing 218 pregnancies, including 215 deliveries and 3 abortions, were summarized using narrative review and descriptive statistics. Successful pregnancies were reported following a diverse range of uterine-sparing prolapse repairs, both native tissue and mesh-augmented, that utilized vaginal, open abdominal, and laparoscopic approaches. We observed shifts from native tissue repairs to mesh-augmented laparoscopic repairs over time. POP recurrence occurred in 12% of subjects overall, 15% after vaginal and 10% after abdominal prolapse repairs. While meta-analysis identified higher recurrence rates after vaginal delivery (15%) than cesarean section (10%), due to small study numbers, multiple confounders, and heterogeneity between studies, no significant differences in recurrence rates could be identified between vaginal and abdominal surgical approaches, utilization of mesh augmentation, or mode of delivery. Conclusion Although literature on pregnancy following uterine-sparing POP repair is limited, available data suggest that prolapse recurrence after pregnancy and delivery remains similar to that after prolapse repair without subsequent pregnancies with few documented perinatal complications. Systematic review registration PROSPERO, CRD42021247722