Molecular engineering of materials for bioreactivity

New classes of materials are being designed to interact specifically with mammalian cells to control their behavior and subsequently direct the formation of organ specific tissue. When a material comes in contact with biological systems, initial events are dominated by protein adsorption, and platel...

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Bibliographic Details
Published in:Current opinion in solid state & materials science 1999-08, Vol.4 (4), p.381-387
Main Author: Healy, Kevin E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bioreactivity
Medical sciences
Molecular engineering
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:New classes of materials are being designed to interact specifically with mammalian cells to control their behavior and subsequently direct the formation of organ specific tissue. When a material comes in contact with biological systems, initial events are dominated by protein adsorption, and platelet, blood and inflammatory cell adhesion. These events constitute what is regarded as the native response to the material and do not represent the optimal behavior between a material and host tissue. A common theme in engineering mammalian cell and tissue behavior is to modify the material to selectively interact with a cell through bimolecular recognition events. Thus, the first step in the process is the rational design of a biomolecular component of the material. This approach to designing materials is commonly referred to as biomimetic engineering of materials. This review focuses on recent papers (i.e. published during late 1997 through early 1999) that incorporate biomimetic engineering to control the bioreactivity of materials: either solid surfaces, linear polymers, or three-dimensional hydrogels. (Example: silanes.)
ISSN:1359-0286
DOI:10.1016/S1359-0286(99)00038-8