Synergistic Charge Percolation in Conducting Polymers Enables High‐Performance In Vivo Sensing of Neurochemical and Neuroelectrical Signals

Challenges remain in establishing a universal method to precisely tune electrochemical properties of conducting polymers for multifunctional neurosensing with high selectivity and sensitivity. Here, we demonstrate a facile and general approach to achieving synergistic charge percolation in conductin...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-10, Vol.61 (41), p.e202204344-n/a
Main Authors: Xu, Tianci, Ji, Wenliang, Zhang, Yue, Wang, Xiaofang, Gao, Nan, Mao, Lanqun, Zhang, Meining
Format: Article
Language:English
Subjects:
Ascorbic acid
Biocompatibility
Carbon nanotubes
Catalysts
Charge Percolation
Conducting Polymers
Electrochemical analysis
Electrochemistry
In Vivo Electrochemistry
Microsensors
Nanotechnology
Nanotubes
Neuroscience
Percolation
Polymers
Reaction kinetics
Selectivity
Synergistic effect
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Challenges remain in establishing a universal method to precisely tune electrochemical properties of conducting polymers for multifunctional neurosensing with high selectivity and sensitivity. Here, we demonstrate a facile and general approach to achieving synergistic charge percolation in conducting polymers (i.e., poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate), PEDOT:PSS) by incorporating conductive catalysts (i.e., carbon nanotubes, CNTs) and post‐processing. The approach shows synergistic effects: (i) CNTs and post‐processing together promote PEDOT ordered interconnection for highly efficient charge percolation that accelerates electrochemical kinetics; (ii) CNTs catalyze the electrooxidation of vitamin C for selective electrochemical sensing; (iii) CNTs enhance the charge storage/injection capacity of PEDOT:PSS. The prepared CNT‐PEDOT:PSS fiber mechanically matches with neural tissues and is proved to be a biocompatible versatile microsensor capable of high‐performance neurosensing in vivo. We report a universal approach that endows conducting polymer (PEDOT:PSS)‐based fiber‐microsensors with an interiorly constructed synergistic charge percolation highway for (i) selective and sensitive sensing of a target neurochemical (vitamin C) and (ii) high‐fidelity sensing of neuronal activities. This strategy is validated through in vivo applications in the nervous system.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202204344