Bone disease in patients with cirrhosis of different etiology and severity; are Klotho protein and osteoprotegerin potential biomarkers?

Cirrhosis is associated with increased risk for osteoporosis and osteopenia. This study aims to further investigate this relationship by examining if etiology and severity of cirrhosis are independent predictors of bone mineral density (BMD) loss. Furthermore we examined the serum levels of osteopro...

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Published in:Scandinavian journal of gastroenterology 2023-02, Vol.58 (2), p.185-192
Main Authors: Katsaounis, Panagiotis V., Hadjiyannis, Emilia S., Skaltsi, Teressa, Anargyrou, Vassiliki A., Alexopoulou, Alexandra A., Dourakis, Spyridon P., Koskinas, John S.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon - adverse effects
Biomarkers
Bone Density
Bone Diseases, Metabolic - etiology
bone mineral density
Cirrhosis
Humans
Klotho protein
Klotho Proteins
Liver Cirrhosis - complications
Osteoporosis - etiology
Osteoprotegerin
vitamin D
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Summary:Cirrhosis is associated with increased risk for osteoporosis and osteopenia. This study aims to further investigate this relationship by examining if etiology and severity of cirrhosis are independent predictors of bone mineral density (BMD) loss. Furthermore we examined the serum levels of osteoprotegerin (OPG) and Klotho proteins that have been involved in bone metabolism. Seventy-four patients with cirrhosis of different etiology and 25 matched healthy controls were included in this study. Bone mineral densitometry at both lumbar spine and femoral neck was measured. Serum total OPG, Klotho protein and vitamin D levels were also determined. Comparisons were performed according to etiology and severity of cirrhosis. Decreased bone density was observed in cirrhotic patients compared to healthy controls with T = −1.46 and T = −1.37 in lumbar spine and femoral bone respectively compared to T = −0.396 and T = −0.672 in the control group. In the cirrhotic group, osteopenia was observed in 46% in lumbar spine and 51% in femoral bone whereas osteoporosis was observed in 20% in lumbar spine and 9% in femoral bone. Decreased bone density was confirmed, regardless of cirrhosis etiology or stage of liver function. Patients were found to have higher levels of OPG than the control group (136 pg/ml vs. 67 pg/ml, p 
ISSN:0036-5521
1502-7708
DOI:10.1080/00365521.2022.2114813