Laparoscopic Proximal Gastrectomy with Novel Valvuloplastic Esophagogastrostomy vs. Laparoscopic Total Gastrectomy for Stage I Gastric Cancer: a Propensity Score Matching Analysis

• Published in: Journal of gastrointestinal surgery 2022-10, Vol.26 (10), p.2041-2049
• Main Authors: Yamamoto, Masaaki, Omori, Takeshi, Shinno, Naoki, Hara, Hisashi, Fujii, Yoshiaki, Mukai, Yosuke, Sugase, Takahito, Takeoka, Tomohira, Asukai, Kei, Kanemura, Takashi, Hasegawa, Shinichiro, Akita, Hirofumi, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Matsuda, Chu, Yasui, Masayoshi, Miyata, Hiroshi, Ohue, Masayuki
• Format: Article
• Language: English
• Subjects: Albumins; Body mass index; Cancer therapies; Esophagus; Gastrectomy; Gastric cancer; Gastroenterology; Gastrointestinal surgery; Hemoglobin; Hemoglobins; Humans; Laparoscopy; Medical personnel; Medicine; Medicine & Public Health; Nutritional status; Original Article; Ostomy; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Postoperative Complications - surgery; Propensity Score; Retrospective Studies; Stomach Neoplasms - surgery; Surgery; Sutures
• ISSN: 1091-255X; 1873-4626
• DOI: 10.1007/s11605-022-05404-y

Background Laparoscopic total gastrectomy for early proximal gastric cancer is widely performed. Recently, the number of laparoscopic proximal gastrectomies performed, a surgery limited to early proximal gastric cancer, has gradually increased. However, evidence for the long-term outcomes of laparoscopic total gastrectomy and laparoscopic proximal gastrectomy is insufficient. Therefore, this study aimed to clarify and compare the long-term outcomes of laparoscopic total gastrectomy and laparoscopic proximal gastrectomy with novel valvuloplastic esophagogastrostomy for treatment of clinical stage I proximal gastric cancer. Methods This study included 111 patients who underwent laparoscopic total gastrectomy or laparoscopic proximal gastrectomy for the treatment of upper third clinical stage I gastric cancer between April 2004 and December 2017. After adjusting for propensity score matching analysis, we compared the postoperative complications, nutritional status, and long-term outcomes between the two groups. Results After matching the inclusion criteria, 56 patients (28 in each group) were enrolled. No significant differences were noted in the postoperative complications between the two groups. While laparoscopic proximal gastrectomy was associated with lower albumin levels, lower body weight loss was seen by 1 year after surgery and higher hemoglobin levels by 1, 2, and 3 years after surgery. No significant differences were observed in the 3-year overall survival and 3-year recurrence-free survival between the laparoscopic total gastrectomy and laparoscopic proximal gastrectomy groups ( P  = 0.74 and 0.72, respectively). Conclusion Laparoscopic proximal gastrectomy and laparoscopic total gastrectomy for patients with upper third clinical stage I gastric cancer are feasible as regards its safety and outcomes.