Race/ethnic differences in the prevalence of osteoporosis, falls and fractures: a cross-sectional analysis of the Canadian Longitudinal Study on Aging

• Published in: Osteoporosis international 2022-12, Vol.33 (12), p.2637-2648
• Main Authors: Morin, Suzanne N., Berger, Claudie, Papaioannou, Alexandra, Cheung, Angela M., Rahme, Elham, Leslie, William D., Goltzman, David
• Format: Article
• Language: English
• Subjects: Aging; Body mass index; Bone density; Bone mineral density; Canadians; Cross-sectional studies; Endocrinology; Epidemiology; Fractures; Longitudinal studies; Medicine; Medicine & Public Health; Original Article; Orthopedics; Osteoporosis; Race; Regression analysis; Rheumatology; Trauma
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-022-06539-z

Summary Most of the published epidemiology on osteoporosis is derived from White populations; still many countries have increasing ethno-culturally diverse populations, leading to gaps in the development of population-specific effective fracture prevention strategies. We describe differences in prevalent fracture and bone mineral density patterns in Canadians of different racial/ethnic backgrounds. Introduction We described prevalent fracture and bone mineral density (BMD) patterns in Canadians by their racial/ethnic backgrounds. Methods For this cross-sectional analysis, we used the Canadian Longitudinal Study on Aging baseline data (2011–2015) of 22,091 randomly selected participants of Black, East Asian, South or Southeast Asian (SSEA) and White race/ethnic backgrounds, aged 45–85 years with available information on the presence or absence of self-reported prevalent low trauma fractures and femoral neck BMD (FNBMD) measurement. Logistic and linear regression models examined associations of race/ethnic background with fracture and FNBMD, respectively. Covariates included sex, age, height, body mass index (BMI), grip strength and physical performance score. Results We identified 11,166 women and 10,925 men. Self-reported race/ethnic backgrounds were: 139 Black, 205 East Asian, 269 SSEA and 21,478 White. White participants were older (mean 62.5 years) than the other groups (60.5 years) and had a higher BMI (28.0 kg/m 2 ) than both Asian groups, but lower than the Black group. The population-weighted prevalence of falls was 10.0%, and that of low trauma fracture was 12.0% ranging from 3.3% (Black) to 12.3% (White), with Black and SSEA Canadians having lower adjusted odds ratios (aOR) of low trauma fractures than White Canadians (Black, aOR = 0.3 [95% confidence interval: 0.1–0.7]; SSEA, aOR = 0.5 [0.3–0.8]). The mean (SD) FNBMD varied between groups: Black, 0.907 g/cm 2 (0.154); East Asian, 0.748 g/cm 2 (0.119); SSEA, 0.769 g/cm 2 (0.134); and White, 0.773 g/cm 2 (0.128). Adjusted linear regressions suggested that Black and both Asian groups had higher FNBMD compared to White. Conclusion Our results support the importance of characterizing bone health predictors in Canadians of different race/ethnic backgrounds to tailor the development of population-specific fracture prevention strategies.